ASY1 DNA-binding HORMA family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ASY1
Official Full Name: DNA-binding HORMA family protein
Primary source: TAIR:AT1G67370
Locus tag: AT1G67370
See related: Araport:AT1G67370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ASYNAPTIC 1; ATASY1; F1N21.19
Summary: meiotic asynaptic mutant 1 (ASY1). ASY1 protein is initially distributed as numerous foci throughout the chromatin. During early G2, the foci are juxtaposed to the nascent chromosome axes to form a continuous axis associated signal.
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Genomic context

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See ASY1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 22

Sequence:: Chromosome: 1; NC_003070.9 (25239117..25243837, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chromoanagenesis in the asy1 meiotic mutant of Arabidopsis.
Title: Chromoanagenesis in the asy1 meiotic mutant of Arabidopsis.
COMET Functions as a PCH2 Cofactor in Regulating the HORMA Domain Protein ASY1.
Title: COMET Functions as a PCH2 Cofactor in Regulating the HORMA Domain Protein ASY1.
State changes of the HORMA protein ASY1 are mediated by an interplay between its closure motif and PCH2.
Title: State changes of the HORMA protein ASY1 are mediated by an interplay between its closure motif and PCH2.
ASY1 acts as a dosage-dependent antagonist of telomere-led recombination and mediates crossover interference in Arabidopsis.
Title: ASY1 acts as a dosage-dependent antagonist of telomere-led recombination and mediates crossover interference in Arabidopsis.
The Arabidopsis Cdk1/Cdk2 homolog CDKA;1 controls chromosome axis assembly during plant meiosis.
Title: The Arabidopsis Cdk1/Cdk2 homolog CDKA;1 controls chromosome axis assembly during plant meiosis.
In the absence of PCH2, the ASY1 signal is not depleted from the chromosome axis and the SC does not form normally.
Title: Arabidopsis PCH2 Mediates Meiotic Chromosome Remodeling and Maturation of Crossovers.
In the absence of ASY1, synapsis is interrupted and chiasma formation is dramatically reduced. ASY1 protein is initially detected during early meiotic G2 as numerous foci distributed over the chromatin.
Title: ASY1 coordinates early events in the plant meiotic recombination pathway.
Data showed that double mutant plants carrying as1/as2 (ASYMMETRIC LEAVES1 and 2 mutants) and mutations of several key transcription factors enhanced as1/as2 defects by producing more severely abaxialized leaves.
Title: Genetic interactions between leaf polarity-controlling genes and ASYMMETRIC LEAVES1 and 2 in Arabidopsis leaf patterning.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_105405.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chiasma assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homologous chromosome pairing at meiosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptonemal complex assembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA-binding HORMA family protein

NP_564896.1

ASYNAPTIC 1 (ASY1); CONTAINS InterPro DOMAIN/s: SWIRM (InterPro:IPR007526), DNA-binding HORMA (InterPro:IPR003511); BEST Arabidopsis thaliana protein match is: DNA-binding HORMA family protein (TAIR:AT4G32200.1); Has 527 Blast hits to 490 proteins in 159 species: Archae - 0; Bacteria - 18; Metazoa - 158; Fungi - 114; Plants - 58; Viruses - 21; Other Eukaryotes - 158 (source: NCBI BLink).