ACHT4 atypical CYS HIS rich thioredoxin 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ACHT4
Official Full Name: atypical CYS HIS rich thioredoxin 4
Primary source: TAIR:AT1G08570
Locus tag: AT1G08570
See related: Araport:AT1G08570
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: atypical CYS HIS rich thioredoxin 4; atypical CYS HIS rich thioredoxin 4
Summary: Encodes a member of the thioredoxin family protein. Located in the chloroplast. Shows high activity towards the chloroplast 2-Cys peroxiredoxin A, and poor activity towards the chloroplast NADP-malate dehydrogenase.
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Genomic context

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See ACHT4 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 5

Sequence:: Chromosome: 1; NC_003070.9 (2712694..2714833)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACHT4 further reacted uniquely with the small subunit APS1, the first committed enzyme of the starch synthesis pathway, suggesting that it transfers the disulfides it receives from 2-Cys Prx to APS1 and turns off AGPase.
Title: ACHT4-driven oxidation of APS1 attenuates starch synthesis under low light intensity in Arabidopsis plants.

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General gene information

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Homology

Orthologs from OrthoDB

NM_001084022.1

Supported by ESTs:

NM_001123776.1

Supported by ESTs:

NM_001123777.1

Supported by ESTs:

NM_100730.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast membrane	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast stroma	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: atypical CYS HIS rich thioredoxin 4

NP_001077491.1

atypical CYS HIS rich thioredoxin 4 (ACHT4); FUNCTIONS IN: oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; INVOLVED IN: cell redox homeostasis; LOCATED IN: chloroplast membrane, chloroplast, chloroplast stroma; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin-like (InterPro:IPR017936), Thioredoxin domain (InterPro:IPR013766), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: atypical CYS HIS rich thioredoxin 3 (TAIR:AT2G33270.1); Has 2537 Blast hits to 2529 proteins in 580 species: Archae - 19; Bacteria - 606; Metazoa - 627; Fungi - 356; Plants - 522; Viruses - 3; Other Eukaryotes - 404 (source: NCBI BLink).

NP_001117248.1

atypical CYS HIS rich thioredoxin 4 (ACHT4); FUNCTIONS IN: oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; INVOLVED IN: cell redox homeostasis; LOCATED IN: chloroplast membrane, chloroplast, chloroplast stroma; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin-like (InterPro:IPR017936), Thioredoxin domain (InterPro:IPR013766), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: atypical CYS HIS rich thioredoxin 3 (TAIR:AT2G33270.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_001117249.1

atypical CYS HIS rich thioredoxin 4 (ACHT4); FUNCTIONS IN: oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; INVOLVED IN: cell redox homeostasis; LOCATED IN: chloroplast membrane, chloroplast, chloroplast stroma; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin-like (InterPro:IPR017936), Thioredoxin domain (InterPro:IPR013766), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: atypical CYS HIS rich thioredoxin 3 (TAIR:AT2G33270.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_172333.1

atypical CYS HIS rich thioredoxin 4 (ACHT4); FUNCTIONS IN: oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; INVOLVED IN: cell redox homeostasis; LOCATED IN: chloroplast membrane, chloroplast, chloroplast stroma; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin-like (InterPro:IPR017936), Thioredoxin domain (InterPro:IPR013766), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: atypical CYS HIS rich thioredoxin 3 (TAIR:AT2G33270.1); Has 2532 Blast hits to 2524 proteins in 582 species: Archae - 19; Bacteria - 596; Metazoa - 625; Fungi - 365; Plants - 524; Viruses - 3; Other Eukaryotes - 400 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

2712694..2714833

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_100730.4 → NP_172333.1 atypical CYS HIS rich thioredoxin 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_172333.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B3H436, O64654

UniProtKB/TrEMBL

A0A178WL40, A0A5S9TCF1

Conserved Domains (1) summary

cd02947
Location:115 → 202

TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
NM_001123776.1 → NP_001117248.1 atypical CYS HIS rich thioredoxin 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001117248.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O64654

Conserved Domains (1) summary

cd02947
Location:17 → 104

TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
NM_001084022.1 → NP_001077491.1 atypical CYS HIS rich thioredoxin 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001077491.1

Status: REVIEWED

UniProtKB/TrEMBL

A8MQQ7

Conserved Domains (1) summary

cd02947
Location:84 → 171

TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
NM_001123777.1 → NP_001117249.1 atypical CYS HIS rich thioredoxin 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001117249.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O64654

Conserved Domains (1) summary

cd02947
Location:17 → 104

TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...