U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MCM4 Minichromosome maintenance (MCM2/3/5) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816142, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MCM4
    Official Full Name
    Minichromosome maintenance (MCM2/3/5) family protein
    Primary source
    TAIR:AT2G16440
    Locus tag
    AT2G16440
    See related
    Araport:AT2G16440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F16F14.6; F16F14_6; MINICHROMOSOME MAINTENANCE 4
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MCM4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    18
    Sequence:
    Chromosome: 2; NC_003071.7 (7126279..7130729, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene purple acid phosphatase 10 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene coiled-coil 90B-like protein (DUF1640)

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. BICELLULAR POLLEN 1 is a modulator of DNA replication and pollen development in Arabidopsis. Long YP, et al. New Phytol, 2019 Apr. PMID 30484867
    2. Dynamic localization of the DNA replication proteins MCM5 and MCM7 in plants. Shultz RW, et al. Plant Physiol, 2009 Jun. PMID 19357199, Free PMC Article
    3. The DNA replication checkpoint aids survival of plants deficient in the novel replisome factor ETG1. Takahashi N, et al. EMBO J, 2008 Jul 9. PMID 18528439, Free PMC Article
    4. Telomerase Interaction Partners-Insight from Plants. Fulnečková J, et al. Int J Mol Sci, 2021 Dec 29. PMID 35008793, Free PMC Article
    5. Tandem affinity purification of AtTERT reveals putative interaction partners of plant telomerase in vivo. Majerská J, et al. Protoplasma, 2017 Jul. PMID 27853871

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_127197.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA unwinding involved in DNA replication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MCM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of THO complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast HDA PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Minichromosome maintenance (MCM2/3/5) family protein
    NP_179236.3
    • MINICHROMOSOME MAINTENANCE 4 (MCM4); FUNCTIONS IN: nucleoside-triphosphatase activity, DNA-dependent ATPase activity, DNA binding, nucleotide binding, ATP binding; INVOLVED IN: cell proliferation, DNA-dependent DNA replication initiation, DNA unwinding involved in replication; LOCATED IN: nuclear chromatin; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), ATPase, AAA+ type, core (InterPro:IPR003593), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 4 (InterPro:IPR008047); BEST Arabidopsis thaliana protein match is: minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT5G44635.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      7126279..7130729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127197.5 → NP_179236.3  Minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179236.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WVF5, Q9SIV8
      UniProtKB/TrEMBL
      A0A178VLY4, A0A5S9WYF4, A0A654EYE1
      Conserved Domains (3) summary
      smart00350
      Location:232 → 747
      MCM; minichromosome maintenance proteins
      PHA03307
      Location:2 → 76
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam14551
      Location:140 → 231
      MCM_N; MCM N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WVF5.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools