PEX7 peroxin 7 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PEX7
Official Full Name: peroxin 7
Primary source: TAIR:AT1G29260
Locus tag: AT1G29260
See related: Araport:AT1G29260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS PEROXIN 7; ATPEX7; F28N24.6; F28N24_6; peroxin 7; PEROXISOMAL TARGETING SIGNAL TYPE 2 RECEPTOR
Summary: Encodes the peroxisomal targeting signal type 2 receptor that facilitates peroxisomal protein translocation. It recognizes proteins with the PTS2 consensus sequence (RLX5HL or a variant) within the first 30 or so amino acids. RNAi experiments suggest that PEX7 is necessary for the maintenance of glyoxysomal but not leaf peroxisomal function.
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Genomic context

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See PEX7 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 1

Sequence:: Chromosome: 1; NC_003070.9 (10224815..10226322)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peroxisomal plant nitric oxide synthase (NOS) protein is imported by peroxisomal targeting signal type 2 (PTS2) in a process that depends on the cytosolic receptor PEX7 and calmodulin
Title: Peroxisomal plant nitric oxide synthase (NOS) protein is imported by peroxisomal targeting signal type 2 (PTS2) in a process that depends on the cytosolic receptor PEX7 and calmodulin.
RabE1c binds PEX7 and facilitates PEX7 degradation in the presence of immobile GFP-PEX7 accumulated at the membrane
Title: Proteomic analysis reveals that the Rab GTPase RabE1c is involved in the degradation of the peroxisomal protein receptor PEX7 (peroxin 7).
PEX7 facilitates PEX5 accumulation and import of PTS1 cargo into peroxisomes
Title: Interdependence of the peroxisome-targeting receptors in Arabidopsis thaliana: PEX7 facilitates PEX5 accumulation and import of PTS1 cargo into peroxisomes.
results suggest that the targeting of PEX7 to peroxisomes requires four proteins: a PTS2-containing protein, PEX14, PEX13 and PEX12.
Title: Molecular components required for the targeting of PEX7 to peroxisomes in Arabidopsis thaliana.
Pex5p and Pex7p play different roles in the maintenance of glyoxysomal and leaf peroxisomal functions in plants
Title: Differential contribution of two peroxisomal protein receptors to the maintenance of peroxisomal functions in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_102666.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables peroxisome matrix targeting signal-2 binding	IEA Inferred from Electronic Annotation more info
enables peroxisome matrix targeting signal-2 binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein import into peroxisome matrix	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein targeting to peroxisome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: peroxin 7

NP_174220.1

peroxin 7 (PEX7); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin family protein / WD-40 repeat family protein (TAIR:AT4G35050.1); Has 47872 Blast hits to 26073 proteins in 704 species: Archae - 44; Bacteria - 5081; Metazoa - 19312; Fungi - 11304; Plants - 6238; Viruses - 0; Other Eukaryotes - 5893 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

10224815..10226322

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102666.4 → NP_174220.1 peroxin 7 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_174220.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LP54, Q9XF57

UniProtKB/TrEMBL

A0A178WDC3, A0A5S9WDX0

Conserved Domains (2) summary

sd00039
Location:63 → 104

7WD40; WD40 repeat [structural motif]

cl29593
Location:11 → 309

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...