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    ERCC1 nucleotide repair protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819685, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ERCC1
    Official Full Name
    nucleotide repair protein
    Primary source
    TAIR:AT3G05210
    Locus tag
    AT3G05210
    See related
    Araport:AT3G05210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T12H1.18; T12H1_18; UV REPAIR DEFICIENT 7; UVR7
    Summary
    encodes a homolog of human ERCC1 protein (yeast RAD10), which is a DNA repair endonuclease. Mutants are sensitive to UV-B and gamma radiation (G2 cell cycle phase arrest) and are defective in dark-repair of pyrimidine pyrimidone dimers. This protein incises the 5' end of damaged DNA, similar to ERCC1/RAD10.
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    Genomic context

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    See ERCC1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    8
    Sequence:
    Chromosome: 3; NC_003074.8 (1479339..1482042)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein Neighboring gene RING/U-box superfamily protein Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene Signal peptidase subunit Neighboring gene mitochondrial editing factor 19

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles of the AtErcc1 protein in recombination. Dubest S, et al. Plant J, 2004 Aug. PMID 15255863
    2. Arabidopsis mutants sensitive to gamma radiation include the homologue of the human repair gene ERCC1. Hefner E, et al. J Exp Bot, 2003 Feb. PMID 12554710
    3. ERCC1/XPF protects short telomeres from homologous recombination in Arabidopsis thaliana. Vannier JB, et al. PLoS Genet, 2009 Feb. PMID 19214203, Free PMC Article
    4. UV- and gamma-radiation sensitive mutants of Arabidopsis thaliana. Jiang CZ, et al. Genetics, 1997 Nov. PMID 9383080, Free PMC Article
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ERCC1 and XPF protect short telomeres from homologous recombination.
      Title: ERCC1/XPF protects short telomeres from homologous recombination in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_111394.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 5'-flap endonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within non-photoreactive DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleotide-excision repair, preincision complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV-B IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    nucleotide repair protein
    NP_187172.1
    • ERCC1; FUNCTIONS IN: 5'-flap endonuclease activity; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Helix-hairpin-helix DNA-binding motif, class 1 (InterPro:IPR003583), DNA repair protein rad10 (InterPro:IPR004579), RuvA domain 2-like (InterPro:IPR010994); Has 658 Blast hits to 452 proteins in 188 species: Archae - 0; Bacteria - 4; Metazoa - 166; Fungi - 153; Plants - 44; Viruses - 0; Other Eukaryotes - 291 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1479339..1482042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337571.1 → NP_001327616.1  nucleotide repair protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LSV8
      Conserved Domains (1) summary
      cd22325
      Location:124 → 251
      ERCC1_C-like; Central domain of ERCC1

    2. NM_111394.5 → NP_187172.1  nucleotide repair protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187172.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9MA98
      UniProtKB/TrEMBL
      A0A178VL77, A0A5S9X985, A0A654F482
      Conserved Domains (2) summary
      cl22429
      Location:266 → 317
      HHH_5; Helix-hairpin-helix domain
      cl40440
      Location:124 → 251
      PDDEXK_nuclease-like; PDDEXK family nucleases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MA98.1

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