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    UBC32 ubiquitin-conjugating enzyme 32 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820956, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UBC32
    Official Full Name
    ubiquitin-conjugating enzyme 32
    Primary source
    TAIR:AT3G17000
    Locus tag
    AT3G17000
    See related
    Araport:AT3G17000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ubiquitin-conjugating enzyme 32
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    Genomic context

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    See UBC32 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (5796930..5799747)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Plant self-incompatibility protein S1 family Neighboring gene RNA polymerases M/15 Kd subunit Neighboring gene heme oxygenase-like, multi-helical Neighboring gene AP2/B3-like transcriptional factor family protein Neighboring gene Adenine nucleotide alpha hydrolases-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HRD1-mediated ERAD tuning of ER-bound E2 is conserved between plants and mammals. Chen Q, et al. Nat Plants, 2016 Jun 20. PMID 27322605
    2. UBC32 mediated oxidative tolerance in Arabidopsis. Cui F, et al. J Genet Genomics, 2012 Aug 20. PMID 22884097
    3. Arabidopsis ubiquitin conjugase UBC32 is an ERAD component that functions in brassinosteroid-mediated salt stress tolerance. Cui F, et al. Plant Cell, 2012 Jan. PMID 22214659, Free PMC Article
    4. ERAD Tuning of the HRD1 Complex Component AtOS9 Is Modulated by an ER-Bound E2, UBC32. Chen Q, et al. Mol Plant, 2017 Jun 5. PMID 28040559
    5. ERAD-related E2 and E3 enzymes modulate the drought response by regulating the stability of PIP2 aquaporins. Chen Q, et al. Plant Cell, 2021 Aug 31. PMID 34015125, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ERAD-related E2 and E3 enzymes modulate the drought response by regulating the stability of PIP2 aquaporins.
      Title: ERAD-related E2 and E3 enzymes modulate the drought response by regulating the stability of PIP2 aquaporins.
    2. negative role in drought stress response
      Title: Arabidopsis group XIV ubiquitin-conjugating enzymes AtUBC32, AtUBC33, and AtUBC34 play negative roles in drought stress response.
    3. UBC32 negatively controls the stability of AtOS9, a component in the HRD1 complex.
      Title: ERAD Tuning of the HRD1 Complex Component AtOS9 Is Modulated by an ER-Bound E2, UBC32.
    4. The plant ubiquitin-conjugating enzyme 32 (UBC32), an ER-bound E2 working in the DOA10 complex, is maintained at low levels under standard conditions by proteasome-dependent degradation mediated by the HRD1 complex, the other E3 complex involved in ERAD.
      Title: HRD1-mediated ERAD tuning of ER-bound E2 is conserved between plants and mammals.
    5. UBC32 mediated oxidative tolerance.
      Title: UBC32 mediated oxidative tolerance in Arabidopsis.
    6. Data supported the contention that UBC32 plays a role in the BR-mediated salt stress response and that BR signaling is necessary for the plant to tolerate salt.
      Title: Arabidopsis ubiquitin conjugase UBC32 is an ERAD component that functions in brassinosteroid-mediated salt stress tolerance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_112576.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to water deprivation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of stomatal opening IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with endoplasmic reticulum IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme 32
    NP_566563.1
    • ubiquitin-conjugating enzyme 32 (UBC32); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin-conjugating enzyme 34 (TAIR:AT1G17280.2); Has 7916 Blast hits to 7914 proteins in 379 species: Archae - 0; Bacteria - 0; Metazoa - 3544; Fungi - 1602; Plants - 1492; Viruses - 20; Other Eukaryotes - 1258 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5796930..5799747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112576.3 → NP_566563.1  ubiquitin-conjugating enzyme 32 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566563.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4TYX9, Q9LSP7
      UniProtKB/TrEMBL
      A0A178V8Q6
      Conserved Domains (1) summary
      cd00195
      Location:13 → 152
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LSP7.1

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