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    BHLH32 basic helix-loop-helix 32 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822159, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BHLH32
    Official Full Name
    basic helix-loop-helix 32
    Primary source
    TAIR:AT3G25710
    Locus tag
    AT3G25710
    See related
    Araport:AT3G25710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATAIG1; basic helix-loop-helix 32; TARGET OF MONOPTEROS 5; TMO5
    Summary
    Encodes a basic helix#Aeiloop#Aeihelix transcription factor that is expressed in the hypophysis-adjacent embryo cells, and is required and partially sufficient for MP-dependent root initiation. Involved in response to phosphate starvation. Negative regulator of root hair development, anthocyanin formation and Pi content.
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    Genomic context

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    See BHLH32 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (9369499..9371487)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Hydroxyproline-rich glycoprotein family protein Neighboring gene Eukaryotic aspartyl protease family protein Neighboring gene tRNA-Ile Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LONESOME HIGHWAY-TARGET OF MONOPTEROS5 transcription factor complex promotes a predifferentiation state for xylem vessel differentiation in the root apical meristem by inducing the expression of VASCULAR-RELATED NAC-DOMAIN genes. Ohashi-Ito K, et al. New Phytol, 2024 May. PMID 38462819
    2. Vascular transcription factors guide plant epidermal responses to limiting phosphate conditions. Wendrich JR, et al. Science, 2020 Nov 13. PMID 32943451, Free PMC Article
    3. Evolution of vascular plants through redeployment of ancient developmental regulators. Lu KJ, et al. Proc Natl Acad Sci U S A, 2020 Jan 7. PMID 31874927, Free PMC Article
    4. Regulation of the Arabidopsis root vascular initial population by LONESOME HIGHWAY. Ohashi-Ito K, et al. Development, 2007 Aug. PMID 17626058, Free PMC Article
    5. MONOPTEROS controls embryonic root initiation by regulating a mobile transcription factor. Schlereth A, et al. Nature, 2010 Apr 8. PMID 20220754

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LONESOME HIGHWAY-TARGET OF MONOPTEROS5 transcription factor complex promotes a predifferentiation state for xylem vessel differentiation in the root apical meristem by inducing the expression of VASCULAR-RELATED NAC-DOMAIN genes.
      Title: LONESOME HIGHWAY-TARGET OF MONOPTEROS5 transcription factor complex promotes a predifferentiation state for xylem vessel differentiation in the root apical meristem by inducing the expression of VASCULAR-RELATED NAC-DOMAIN genes.
    2. Vascular transcription factors guide plant epidermal responses to limiting phosphate conditions.
      Title: Vascular transcription factors guide plant epidermal responses to limiting phosphate conditions.
    3. Study revealed the evolutionary trajectory for the heterodimeric TMO5/LHW transcription factor complex, which is rate-limiting for vascular cell proliferation in Arabidopsis thaliana. Both regulators have origins predating vascular tissue emergence, and even terrestrialization. TMO5 evolved its modern function, including dimerization with LHW, at the origin of land plants.
      Title: Evolution of vascular plants through redeployment of ancient developmental regulators.
    4. TARGET OF MP, TMO5 and TMO7 encode basic helix-loop-helix (bHLH) transcription factors that are expressed in the hypophysis-adjacent embryo cells, and are required and partially sufficient for MONOPTEROS-dependent root initiation. [TMO5]
      Title: MONOPTEROS controls embryonic root initiation by regulating a mobile transcription factor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_113470.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anthocyanin-containing compound biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to phosphate starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    basic helix-loop-helix 32
    NP_189199.1
    • basic helix-loop-helix 32 (BHLH32); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT1G68810.1); Has 2800 Blast hits to 2795 proteins in 201 species: Archae - 0; Bacteria - 0; Metazoa - 397; Fungi - 30; Plants - 2368; Viruses - 0; Other Eukaryotes - 5 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      9369499..9371487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113470.3 → NP_189199.1  basic helix-loop-helix 32 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189199.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LS08
      UniProtKB/TrEMBL
      A0A178VA88, A0A5S9XFL3
      Conserved Domains (2) summary
      cd11455
      Location:126 → 204
      bHLH_AtAIG1_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein AIG1 and similar proteins
      cl09141
      Location:218 → 306
      ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LS08.1

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