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    POLGAMMA2 polymerase gamma 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841506, updated on 18-Sep-2024

    Summary

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    Official Symbol
    POLGAMMA2
    Official Full Name
    polymerase gamma 2
    Primary source
    TAIR:AT1G50840
    Locus tag
    AT1G50840
    See related
    Araport:AT1G50840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F8A12.8; F8A12_8; PolIA; polymerase gamma 2; polymerase I A
    Summary
    DNA Polymerase gamma2. Dual targeting to mitochondria and plastids due to alternative translation initiation.
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    Genomic context

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    See POLGAMMA2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (18839047..18844577)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene aminotransferase-like, mobile domain protein Neighboring gene pseudo Neighboring gene Aminotransferase-like, plant mobile domain family protein Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Participation of leaky ribosome scanning in protein dual targeting by alternative translation initiation in higher plants. Wamboldt Y, et al. Plant Cell, 2009 Jan. PMID 19182105, Free PMC Article
    2. Identification of a unique insertion in plant organellar DNA polymerases responsible for 5'-dRP lyase and strand-displacement activities: Implications for Base Excision Repair. Trasviña-Arenas CH, et al. DNA Repair (Amst), 2018 May. PMID 29522990
    3. Plant organellar DNA polymerases are replicative and translesion DNA synthesis polymerases. Baruch-Torres N, et al. Nucleic Acids Res, 2017 Oct 13. PMID 28977655, Free PMC Article
    4. Divergent roles for the two PolI-like organelle DNA polymerases of Arabidopsis. Parent JS, et al. Plant Physiol, 2011 May. PMID 21427281, Free PMC Article
    5. Arabidopsis thaliana organelles mimic the T7 phage DNA replisome with specific interactions between Twinkle protein and DNA polymerases Pol1A and Pol1B. Morley SA, et al. BMC Plant Biol, 2019 Jun 6. PMID 31170927, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The interaction of Twinkle with Pol1A or Pol1B mimics the minimal DNA replisomes of T7 phage and those present in mammalian mitochondria. However, while T7 and mammals absolutely require their homolog of Twinkle DNA helicase-primase, Arabidopsis Twinkle mutants are seemingly unaffected by this loss.
      Title: Arabidopsis thaliana organelles mimic the T7 phage DNA replisome with specific interactions between Twinkle protein and DNA polymerases Pol1A and Pol1B.
    2. PolIA & PolIB are functionally equipped to play a role in short-patch BER and suggest a major role of PolIA & PolIB in a predicted long-patch base excision repair (BER) sub-pathway. We propose that the acquisition of insertion 1 in the polymerization domain of PolIA & PolIB was a key component in their evolution as BER associated and replicative DNA polymerases.
      Title: Identification of a unique insertion in plant organellar DNA polymerases responsible for 5'-dRP lyase and strand-displacement activities: Implications for Base Excision Repair.
    3. both AtPolIA and AtPolIB are efficient translesion DNA synthesis polymerases, providing the first example of a family-A DNAP with an active exonuclease domain that efficiently bypasses an AP site.
      Title: Plant organellar DNA polymerases are replicative and translesion DNA synthesis polymerases.
    4. Alternative translation initiation in Polgamma2 involves leaky ribosome scanning of both cis- and trans-acting components.
      Title: Participation of leaky ribosome scanning in protein dual targeting by alternative translation initiation in higher plants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_103965.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitochondrial DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plastid DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polymerase gamma 2
    NP_175498.2
    • polymerase gamma 2 (POLGAMMA2); FUNCTIONS IN: DNA binding, DNA-directed DNA polymerase activity; INVOLVED IN: DNA replication, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA-directed DNA polymerase, family A, palm domain (InterPro:IPR001098), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA polymerase A domain (InterPro:IPR002298), 3'-5' exonuclease (InterPro:IPR002562); BEST Arabidopsis thaliana protein match is: polymerase gamma 1 (TAIR:AT3G20540.1); Has 11974 Blast hits to 10011 proteins in 2572 species: Archae - 0; Bacteria - 6712; Metazoa - 149; Fungi - 0; Plants - 122; Viruses - 286; Other Eukaryotes - 4705 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18839047..18844577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333457.1 → NP_001321058.1  polymerase gamma 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8APQ6, A0A5S9WNC2

    2. NM_103965.5 → NP_175498.2  polymerase gamma 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175498.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I6M1, Q8W105, Q9C6J5
      UniProtKB/TrEMBL
      A0A5S9WNC2
      Conserved Domains (3) summary
      cd08640
      Location:639 → 1048
      DNA_pol_A_plastid_like; DNA polymerase A type from plastids of higher plants possibly involve in DNA replication or in the repair of errors occurring during replication
      cd06139
      Location:290 → 523
      DNA_polA_I_Ecoli_like_exo; DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases
      COG0749
      Location:305 → 1050
      PolA; DNA polymerase I - 3'-5' exonuclease and polymerase domains [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4I6M1.1

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