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    SUVH2 SU(VAR)3-9 homolog 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817892, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SUVH2
    Official Full Name
    SU(VAR)3-9 homolog 2
    Primary source
    TAIR:AT2G33290
    Locus tag
    AT2G33290
    See related
    Araport:AT2G33290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSUVH2; F4P9.6; F4P9_6; SDG3; SET DOMAIN-CONTAINING PROTEIN 3; SU(VAR)3-9 homolog 2
    Summary
    Encodes a SU(VAR)3-9 homolog, a SET domain protein. Known SET domain proteins are involved in epigenetic control of gene expression and act as histone methyltransferases. There are 10 SUVH genes in Arabidopsis and members of this subfamily of the SET proteins have an additional conserved SRA domain. Gene is expressed in rosettes, stems, floral buds, and flowers by RT-PCR.
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    Genomic context

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    See SUVH2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (14108529..14112464)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene atypical CYS HIS rich thioredoxin 3 Neighboring gene Major facilitator superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transcription elongation factor (TFIIS) family protein Neighboring gene auxin-induced protein 13 Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SUVH2 and SUVH9 Couple Two Essential Steps for Transcriptional Gene Silencing in Arabidopsis. Jing Y, et al. Mol Plant, 2016 Aug 1. PMID 27216319
    2. SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Johnson LM, et al. Nature, 2014 Mar 6. PMID 24463519, Free PMC Article
    3. Developmentally non-redundant SET domain proteins SUVH2 and SUVH9 are required for transcriptional gene silencing in Arabidopsis thaliana. Kuhlmann M, et al. Plant Mol Biol, 2012 Aug. PMID 22669745, Free PMC Article
    4. Epigenetic programming via histone methylation at WRKY53 controls leaf senescence in Arabidopsis thaliana. Ay N, et al. Plant J, 2009 Apr. PMID 19143996
    5. Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis. Naumann K, et al. EMBO J, 2005 Apr 6. PMID 15775980, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNA polymerase epsilon interacts with SUVH2/9 to repress the expression of genes associated with meiotic DSB hotspot in Arabidopsis.
      Title: DNA polymerase epsilon interacts with SUVH2/9 to repress the expression of genes associated with meiotic DSB hotspot in Arabidopsis.
    2. Study propose that SUVH2 and SUVH9 bind to the methylated DNA and facilitate the recruitment of a chromatin-remodeling complex to the target loci in association with MORC proteins.
      Title: SUVH2 and SUVH9 Couple Two Essential Steps for Transcriptional Gene Silencing in Arabidopsis.
    3. Our CHIP assay demonstrated that SUVH2 and SUVH9 are required for the occupancy of Pol V at RdDM loci and facilitate the production of Pol V-dependent noncoding RNAs
      Title: The SET domain proteins SUVH2 and SUVH9 are required for Pol V occupancy at RNA-directed DNA methylation loci.
    4. SUVH2 and SUVH9 functions in RdDM and TGS are overlapping. Pol V specific transcripts were reduced in suvh2 suvh9 plants. This might indicate a role of these SUVH proteins in Pol V complex recruitment.
      Title: Developmentally non-redundant SET domain proteins SUVH2 and SUVH9 are required for transcriptional gene silencing in Arabidopsis thaliana.
    5. SUVH2 overexpression inhibits senescence-associated global changes in chromatin organization.
      Title: Epigenetic programming via histone methylation at WRKY53 controls leaf senescence in Arabidopsis thaliana.
    6. SRA-domain proteins (SUVH2) are also essential for DRM2-mediated de novo and maintenance DNA methylation in Arabidopsis thaliana.
      Title: SRA-domain proteins required for DRM2-mediated de novo DNA methylation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001336444.1
    NM_001336446.1
    NM_128889.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within epigenetic regulation of gene expression TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in gene silencing by siRNA-directed DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SU(VAR)3-9 homolog 2
    NP_001318341.1
    • SU(VAR)3-9 homolog 2 (SUVH2); CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), SRA-YDG (InterPro:IPR003105), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: SU(VAR)3-9 homolog 9 (TAIR:AT4G13460.2); Has 2532 Blast hits to 2457 proteins in 202 species: Archae - 0; Bacteria - 14; Metazoa - 1497; Fungi - 199; Plants - 683; Viruses - 0; Other Eukaryotes - 139 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      14108529..14112464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336445.1 → NP_001324077.1  SU(VAR)3-9 homolog 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22781
      UniProtKB/TrEMBL
      A0A654EYF6

    2. NM_001336444.1 → NP_001318341.1  SU(VAR)3-9 homolog 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22781
      UniProtKB/TrEMBL
      A0A654EYF6

    3. NM_001336446.1 → NP_001324078.1  SU(VAR)3-9 homolog 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22781
      UniProtKB/TrEMBL
      A0A654EYF6

    4. NM_128889.3 → NP_180887.1  SU(VAR)3-9 homolog 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180887.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22781
      UniProtKB/TrEMBL
      A0A654EYF6
      Conserved Domains (3) summary
      smart00466
      Location:202 → 358
      SRA; SET and RING finger associated domain
      smart00317
      Location:495 → 642
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam05033
      Location:389 → 487
      Pre-SET; Pre-SET motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22781.1

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