WIN2 HOPW1-1-interacting 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: WIN2
Official Full Name: HOPW1-1-interacting 2
Primary source: TAIR:AT4G31750
Locus tag: AT4G31750
See related: Araport:AT4G31750
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F28M20.60; F28M20_60; HOPW1-1-interacting 2
Summary: Encodes HopW1-1-Interacting protein 2 (WIN2). Interacts with the P. syringae effector HopW1-1. WIN2 has protein phosphatase activity. Modulates plant defenses against bacteria. Three WIN proteins are identified so far (WIN1: AT1G80600; WIN2: AT4G31750; WIN3: AT5G13320).
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Genomic context

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See WIN2 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 10

Sequence:: Chromosome: 4; NC_003075.7 (15363708..15367892, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

Orthologs from OrthoDB

NM_001342110.1

Supported by ESTs:

NM_001342111.1

Supported by ESTs:

NM_119324.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: HOPW1-1-interacting 2

NP_194903.2

HOPW1-1-interacting 2 (WIN2); FUNCTIONS IN: protein serine/threonine phosphatase activity; INVOLVED IN: protein amino acid dephosphorylation, defense response to bacterium; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C, manganese/magnesium aspartate binding site (InterPro:IPR000222), Protein phosphatase 2C-related (InterPro:IPR001932), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045); BEST Arabidopsis thaliana protein match is: Protein phosphatase 2C family protein (TAIR:AT5G24940.1); Has 8917 Blast hits to 8860 proteins in 1196 species: Archae - 18; Bacteria - 2164; Metazoa - 1691; Fungi - 821; Plants - 2764; Viruses - 9; Other Eukaryotes - 1450 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

15363708..15367892 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119324.4 → NP_194903.2 HOPW1-1-interacting 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194903.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O81773, Q8RXV3

UniProtKB/TrEMBL

A0A178UT68, A0A5S9XYF1

Conserved Domains (1) summary

cd00143
Location:32 → 279

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
NM_001342110.1 → NP_001328539.1 HOPW1-1-interacting 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B4X7
NM_001342111.1 → NP_001328538.1 HOPW1-1-interacting 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O81773, Q8RXV3

UniProtKB/TrEMBL

A0A178UT68, A0A5S9XYF1

Conserved Domains (1) summary

cd00143
Location:32 → 279

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...