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    ADF1 actin depolymerizing factor 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823744, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ADF1
    Official Full Name
    actin depolymerizing factor 1
    Primary source
    TAIR:AT3G46010
    Locus tag
    AT3G46010
    See related
    Araport:AT3G46010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    actin depolymerizing factor 1; atadf; ATADF1
    Summary
    Actin-depolymerizing factor (ADF) and cofilin define a family of actin-binding proteins essential for the rapid turnover of filamentous actin in vivo.
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    Genomic context

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    See ADF1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (16909217..16910845, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Cofilin/tropomyosin-type actin-binding protein family Neighboring gene actin depolymerizing factor 2 Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene Histone superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis AtADF1 is functionally affected by mutations on actin binding sites. Dong CH, et al. J Integr Plant Biol, 2013 Mar. PMID 23190411
    2. ADF proteins are involved in the control of flowering and regulate F-actin organization, cell expansion, and organ growth in Arabidopsis. Dong CH, et al. Plant Cell, 2001 Jun. PMID 11402164, Free PMC Article
    3. A comparative structural analysis of the ADF/cofilin family. Bowman GD, et al. Proteins, 2000 Nov 15. PMID 11025548
    4. Actin Depolymerization Factor ADF1 Regulated by MYB30 Plays an Important Role in Plant Thermal Adaptation. Wang L, et al. Int J Mol Sci, 2023 Mar 16. PMID 36982748, Free PMC Article
    5. Arabidopsis ADF1 is Regulated by MYB73 and is Involved in Response to Salt Stress Affecting Actin Filament Organization. Wang L, et al. Plant Cell Physiol, 2021 Nov 17. PMID 34086948

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Actin Depolymerization Factor ADF1 Regulated by MYB30 Plays an Important Role in Plant Thermal Adaptation.
      Title: Actin Depolymerization Factor ADF1 Regulated by MYB30 Plays an Important Role in Plant Thermal Adaptation.
    2. Arabidopsis ADF1 is Regulated by MYB73 and is Involved in Response to Salt Stress Affecting Actin Filament Organization.
      Title: Arabidopsis ADF1 is Regulated by MYB73 and is Involved in Response to Salt Stress Affecting Actin Filament Organization.
    3. Data show that 14-3-3 lambda is required for actin depolymerizing factor 1 (ADF1) phosphorylation and subcellular localization.
      Title: 14-3-3 λ protein interacts with ADF1 to regulate actin cytoskeleton dynamics in Arabidopsis.
    4. These results demonstrate a regulatory function of Arabidopsis CDPK6 in the N-terminal phosphorylation of AtADF1.
      Title: Arabidopsis CDPK6 phosphorylates ADF1 at N-terminal serine 6 predominantly.
    5. Arabidopsis AtADF1 is functionally affected by mutations on actin binding sites.
      Title: Arabidopsis AtADF1 is functionally affected by mutations on actin binding sites.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084778.1
    NM_114470.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables actin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    actin depolymerizing factor 1
    NP_001078247.1
    • actin depolymerizing factor 1 (ADF1); FUNCTIONS IN: actin binding; INVOLVED IN: actin filament organization; LOCATED IN: intracellular; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Actin-binding, cofilin/tropomyosin type (InterPro:IPR002108); BEST Arabidopsis thaliana protein match is: actin depolymerizing factor 4 (TAIR:AT5G59890.1); Has 1496 Blast hits to 1495 proteins in 262 species: Archae - 0; Bacteria - 3; Metazoa - 635; Fungi - 158; Plants - 513; Viruses - 0; Other Eukaryotes - 187 (source: NCBI BLink).
    NP_190187.1
    • actin depolymerizing factor 1 (ADF1); FUNCTIONS IN: actin binding; INVOLVED IN: actin filament organization; LOCATED IN: intracellular; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Actin-binding, cofilin/tropomyosin type (InterPro:IPR002108); BEST Arabidopsis thaliana protein match is: actin depolymerizing factor 4 (TAIR:AT5G59890.1); Has 1496 Blast hits to 1495 proteins in 266 species: Archae - 0; Bacteria - 3; Metazoa - 633; Fungi - 166; Plants - 513; Viruses - 0; Other Eukaryotes - 181 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      16909217..16910845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114470.3 → NP_190187.1  actin depolymerizing factor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190187.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39250
      UniProtKB/TrEMBL
      A0A178VEL2, A0A7G2EU81
      Conserved Domains (1) summary
      cd11286
      Location:6 → 138
      ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors

    2. NM_001084778.1 → NP_001078247.1  actin depolymerizing factor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078247.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FE42, A8MR09
      Conserved Domains (1) summary
      cd11286
      Location:17 → 149
      ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39250.1

    Gene LinkOut

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