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    NAC062 NAC domain containing protein 62 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824115, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NAC062
    Official Full Name
    NAC domain containing protein 62
    Primary source
    TAIR:AT3G49530
    Locus tag
    AT3G49530
    See related
    Araport:AT3G49530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ANAC062; NAC domain containing protein 62; NTL6; NTM1 (NAC WITH TRANSMEMBRANE MOTIF 1)-LIKE 6
    Summary
    Transcription factor that serves as a molecular link between cold signals and pathogen resistance responses. Undergoes proteolytic processing triggered by cold-induced changes in membrane fluidity.
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    Genomic context

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    See NAC062 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (18362443..18364959, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene F-box family protein Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene uncharacterized protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A plasma membrane-tethered transcription factor, NAC062/ANAC062/NTL6, mediates the unfolded protein response in Arabidopsis. Yang ZT, et al. Plant J, 2014 Sep. PMID 24961665
    2. Proteolytic processing of an Arabidopsis membrane-bound NAC transcription factor is triggered by cold-induced changes in membrane fluidity. Seo PJ, et al. Biochem J, 2010 Apr 14. PMID 20156199
    3. A membrane-bound NAC transcription factor as an integrator of biotic and abiotic stress signals. Seo PJ, et al. Plant Signal Behav, 2010 May. PMID 20139739, Free PMC Article
    4. Cold activation of a plasma membrane-tethered NAC transcription factor induces a pathogen resistance response in Arabidopsis. Seo PJ, et al. Plant J, 2010 Feb. PMID 19947982
    5. Controlled nuclear import of the transcription factor NTL6 reveals a cytoplasmic role of SnRK2.8 in the drought-stress response. Kim MJ, et al. Biochem J, 2012 Dec 15. PMID 22967043

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the membrane-associated transcription factor NAC062 relays endoplasmic reticulum (ER) stress signaling from the plasma membrane to the nucleus and plays important roles in regulating unfolded protein response (UPR)downstream gene expression.
      Title: A plasma membrane-tethered transcription factor, NAC062/ANAC062/NTL6, mediates the unfolded protein response in Arabidopsis.
    2. NTL6 plays an integrative role in plant responses to both biotic and abiotic stress conditions.
      Title: A membrane-bound NAC transcription factor as an integrator of biotic and abiotic stress signals.
    3. Transgenic plants overproducing either NTL6 or its active form 6deltaC exhibit enhanced resistance to water-deficit conditions.
      Title: Controlled nuclear import of the transcription factor NTL6 reveals a cytoplasmic role of SnRK2.8 in the drought-stress response.
    4. NTL6 activation is triggered by exposure to cold, and the transcriptionally active form of NTL6 induces the expression of PR genes by directly binding to the gene promoters and enhances plant resistance to pathogen infection.
      Title: Cold activation of a plasma membrane-tethered NAC transcription factor induces a pathogen resistance response in Arabidopsis.
    5. The observations indicate that a metalloprotease activity is responsible for NTL6 processing in response to cold-induced changes in membrane fluidity.
      Title: Proteolytic processing of an Arabidopsis membrane-bound NAC transcription factor is triggered by cold-induced changes in membrane fluidity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001339427.1
    NM_114813.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to other organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NAC domain containing protein 62
    NP_190522.1
    • NAC domain containing protein 62 (NAC062); CONTAINS InterPro DOMAIN/s: No apical meristem (NAM) protein (InterPro:IPR003441); BEST Arabidopsis thaliana protein match is: TCV-interacting protein (TAIR:AT5G24590.2); Has 2933 Blast hits to 2926 proteins in 76 species: Archae - 0; Bacteria - 2; Metazoa - 0; Fungi - 0; Plants - 2931; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      18362443..18364959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114813.4 → NP_190522.1  NAC domain containing protein 62 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190522.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SCK6
      UniProtKB/TrEMBL
      A0A178VG16, A0A5S9XJK4
      Conserved Domains (1) summary
      pfam02365
      Location:16 → 57
      NAM; No apical meristem (NAM) protein

    2. NM_001339427.1 → NP_001326200.1  NAC domain containing protein 62 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VG16, A0A1I9LNJ5, A0A5S9XJK4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SCK6.1

    Gene LinkOut

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