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    DL1E DYNAMIN-like 1E [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825189, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DL1E
    Official Full Name
    DYNAMIN-like 1E
    Primary source
    TAIR:AT3G60190
    Locus tag
    AT3G60190
    See related
    Araport:AT3G60190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ADL1E; ADL4; ADLP2; ARABIDOPSIS DYNAMIN-LIKE 4; DRP1E; DYNAMIN-like 1E; DYNAMIN-LIKE PROTEIN 2; DYNAMIN-RELATED PROTEIN 1E; EDR3; ENHANCED DISEASE RESISTANCE 3; F27H5.4
    Summary
    At3g60190 encodes Arabidopsis dynamin-related protein 1E, DRP1E, also known as EDR3, ADL4 and ADL1E, which is 624 amino acid residues long, has a predicted mass of 69.8 kDa and a pI of 7.5. Dynamin-related protein 1E belongs to a plant-specific subclass of dynamin-related proteins (DRP1), consisting of five members in Arabidopsis (A, B, C, D, E). This class is characterized by having an N-terminal GTPase domain, a central #Aeodynamin 2#Aeo domain and a C-terminal GTPase effector domain (GED), a typical structure for plant dynamin-related proteins. However, this class lacks a PH domain and a proline-rich domain, which are found in classical animal dynamin-like proteins. Based on work on animal dynamins, the plant DRP1 proteins should be able to form polymeric structures that wrap around membranes to facilitate membrane tubulation and pinching off of vesicles, processes that are essential to vesicle trafficking and membrane compartmentalization. The edr3 mutation causes a P77L substitution in the G2 motif of the GTPase domain of DRP1E. edr3 mutant Arabidopsis plants display enhanced cell death in response to powdery mildew infection.
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    Genomic context

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    See DL1E in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    15
    Sequence:
    Chromosome: 3; NC_003074.8 (22244169..22247976, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene uncharacterized protein Neighboring gene GroES-like family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutation in the GTP hydrolysis site of Arabidopsis dynamin-related protein 1E confers enhanced cell death in response to powdery mildew infection. Tang D, et al. Plant J, 2006 Jul. PMID 16824181, Free PMC Article
    2. The arabidopsis cell plate-associated dynamin-like protein, ADL1Ap, is required for multiple stages of plant growth and development. Kang BH, et al. Plant Physiol, 2001 May. PMID 11351070, Free PMC Article
    3. The brassinosteroid insensitive1-like3 signalosome complex regulates Arabidopsis root development. Fàbregas N, et al. Plant Cell, 2013 Sep. PMID 24064770, Free PMC Article
    4. Interactome of the plant-specific ESCRT-III component AtVPS2.2 in Arabidopsis thaliana. Ibl V, et al. J Proteome Res, 2012 Jan 1. PMID 22010978, Free PMC Article
    5. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The edr3 mutant suggests a mechanistic link between salicylic acid signaling, mitochondria and programmed cell death in plants.
      Title: A mutation in the GTP hydrolysis site of Arabidopsis dynamin-related protein 1E confers enhanced cell death in response to powdery mildew infection.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_115882.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    DYNAMIN-like 1E
    NP_567094.1
    • DYNAMIN-like 1E (DL1E); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: response to cadmium ion, vesicle-mediated transport, defense response to fungus; LOCATED IN: mitochondrion, plasma membrane, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin GTPase effector (InterPro:IPR003130), Dynamin, GTPase domain (InterPro:IPR001401), Dynamin, GTPase region, conserved site (InterPro:IPR019762), GTPase effector domain, GED (InterPro:IPR020850), Dynamin central region (InterPro:IPR000375); BEST Arabidopsis thaliana protein match is: DYNAMIN-like 1D (TAIR:AT2G44590.3); Has 2915 Blast hits to 2753 proteins in 324 species: Archae - 2; Bacteria - 53; Metazoa - 1058; Fungi - 869; Plants - 577; Viruses - 0; Other Eukaryotes - 356 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      22244169..22247976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115882.4 → NP_567094.1  DYNAMIN-like 1E [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567094.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FNX5, Q9M1C4, Q9SE82
      UniProtKB/TrEMBL
      A0A5S9XN78, A0A654FJF4
      Conserved Domains (3) summary
      cd08771
      Location:40 → 306
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:228 → 493
      Dynamin_M; Dynamin central region
      pfam02212
      Location:531 → 620
      GED; Dynamin GTPase effector domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FNX5.1

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