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    ML4 MEI2-like 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830620, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ML4
    Official Full Name
    MEI2-like 4
    Primary source
    TAIR:AT5G07290
    Locus tag
    AT5G07290
    See related
    Araport:AT5G07290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AML4; MEI2-like 4; T28J14.230; T28J14_230
    Summary
    AML4 A member of mei2-like gene family, predominantly plant-based family of genes encoding RNA binding proteins with characteristic presence of a highly conserved RNA binding motif first described in the mei2 gene of the fission yeast S. pombe. In silico analyses reveal nine mei2 -like genes in A. thaliana. They were grouped into four distinct clades, based on overall sequence similarity and subfamily-specific sequence elements. AML4 is a member of two sister clades of mei2-like gene family, AML1 through AML5, and belongs to the clade named ALM14. AML4 is expressed during embryo development (heart and torpedo stage) and in vegetative and floral apices.
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    Genomic context

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    See ML4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Sequence:
    Chromosome: 5; NC_003076.8 (2293114..2298976)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat transmembrane protein kinase Neighboring gene ncRNA Neighboring gene Calcium-dependent phospholipid-binding Copine family protein Neighboring gene Integrase-type DNA-binding superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis-mei2-like genes play a role in meiosis and vegetative growth in Arabidopsis. Kaur J, et al. Plant Cell, 2006 Mar. PMID 16473967, Free PMC Article
    2. PLASTOCHRON2 regulates leaf initiation and maturation in rice. Kawakatsu T, et al. Plant Cell, 2006 Mar. PMID 16461585, Free PMC Article
    3. In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings. Reichel M, et al. Plant Cell, 2016 Oct. PMID 27729395, Free PMC Article
    4. Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method. Bach-Pages M, et al. Biomolecules, 2020 Apr 24. PMID 32344669, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_120811.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within meristem development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    MEI2-like 4
    NP_196346.1
    • MEI2-like 4 (ML4); FUNCTIONS IN: RNA binding, nucleotide binding, nucleic acid binding; INVOLVED IN: meristem development; LOCATED IN: cellular_component unknown; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), RNA recognition motif 2 (InterPro:IPR007201), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: MEI2-like protein 1 (TAIR:AT5G61960.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2293114..2298976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120811.5 → NP_196346.1  MEI2-like 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196346.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LYN7
      UniProtKB/TrEMBL
      A0A178UM13, A0A654FZ73
      Conserved Domains (4) summary
      pfam04059
      Location:741 → 837
      RRM_2; RNA recognition motif 2
      COG0724
      Location:655 → 898
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12276
      Location:295 → 364
      RRM2_MEI2_EAR1_like; RNA recognition motif 2 in Mei2-like proteins and terminal EAR1-like proteins
      cd12524
      Location:210 → 286
      RRM1_MEI2_like; RNA recognition motif 1 in plant Mei2-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LYN7.1

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