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    ACAT2 acetoacetyl-CoA thiolase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834876, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACAT2
    Official Full Name
    acetoacetyl-CoA thiolase 2
    Primary source
    TAIR:AT5G48230
    Locus tag
    AT5G48230
    See related
    Araport:AT5G48230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AACT2; acetoacetyl-CoA thiolase 2; Acetoacetyl-CoA thiolase 2; EMB1276; EMBRYO DEFECTIVE 1276; MIF21.12; MIF21_12
    Summary
    Encodes an acetoacetyl-CoA thiolase that generates the bulk of the acetoacetyl-CoA precursor needed for the cytosolic localized, mevalonate-derived isoprenoids biosynthetic pathway. Loss-of-function mutants are embryo lethal.
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    Genomic context

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    See ACAT2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Sequence:
    Chromosome: 5; NC_003076.8 (19552142..19555531, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene zinc ion binding protein Neighboring gene prolamin-like protein (DUF1278) Neighboring gene Aldolase-type TIM barrel family protein Neighboring gene Rrp15p protein Neighboring gene B-box type zinc finger protein with CCT domain-containing protein Neighboring gene DUF868 family protein (DUF868)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reverse genetic characterization of two paralogous acetoacetyl CoA thiolase genes in Arabidopsis reveals their importance in plant growth and development. Jin H, et al. Plant J, 2012 Jun. PMID 22332816
    2. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article
    3. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    4. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article
    5. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_124198.4
    NM_180823.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables acetyl-CoA C-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetyl-CoA C-acetyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within pollen germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    acetoacetyl-CoA thiolase 2
    NP_568694.2
    • acetoacetyl-CoA thiolase 2 (ACAT2); FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, acetyl-CoA C-acetyltransferase activity, catalytic activity; INVOLVED IN: embryo development ending in seed dormancy; LOCATED IN: peroxisome, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase (InterPro:IPR002155), Thiolase, active site (InterPro:IPR020610), Thiolase, N-terminal (InterPro:IPR020616), Thiolase, conserved site (InterPro:IPR020613), Thiolase, C-terminal (InterPro:IPR020617), Thiolase-like, subgroup (InterPro:IPR016038), Thiolase-like (InterPro:IPR016039), Thiolase, acyl-enzyme intermediate active site (InterPro:IPR020615); BEST Arabidopsis thaliana protein match is: Thiolase family protein (TAIR:AT5G47720.4); Has 23891 Blast hits to 23860 proteins in 2352 species: Archae - 483; Bacteria - 15387; Metazoa - 1000; Fungi - 680; Plants - 248; Viruses - 0; Other Eukaryotes - 6093 (source: NCBI BLink).
    NP_851154.1
    • acetoacetyl-CoA thiolase 2 (ACAT2); FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, acetyl-CoA C-acetyltransferase activity, catalytic activity; INVOLVED IN: embryo development ending in seed dormancy; LOCATED IN: peroxisome, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase (InterPro:IPR002155), Thiolase, active site (InterPro:IPR020610), Thiolase, N-terminal (InterPro:IPR020616), Thiolase, conserved site (InterPro:IPR020613), Thiolase, C-terminal (InterPro:IPR020617), Thiolase-like, subgroup (InterPro:IPR016038), Thiolase-like (InterPro:IPR016039), Thiolase, acyl-enzyme intermediate active site (InterPro:IPR020615); BEST Arabidopsis thaliana protein match is: Thiolase family protein (TAIR:AT5G47720.4); Has 23880 Blast hits to 23851 proteins in 2352 species: Archae - 481; Bacteria - 15387; Metazoa - 998; Fungi - 680; Plants - 247; Viruses - 0; Other Eukaryotes - 6087 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19552142..19555531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124198.4 → NP_568694.2  acetoacetyl-CoA thiolase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568694.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S4Y1, Q93YW6, Q9LUB1
      UniProtKB/TrEMBL
      A0A178UNN7, A0A384LBS2, A0A7G2FHL8, B9DGQ1
      Conserved Domains (1) summary
      PLN02644
      Location:11 → 403
      PLN02644; acetyl-CoA C-acetyltransferase

    2. NM_180823.3 → NP_851154.1  acetoacetyl-CoA thiolase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851154.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2FHL8
      Conserved Domains (2) summary
      PLN02644
      Location:7 → 398
      PLN02644; acetyl-CoA C-acetyltransferase
      cd00751
      Location:10 → 378
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8S4Y1.1

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