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    NADP-ME3 NADP-malic enzyme 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832657, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NADP-ME3
    Official Full Name
    NADP-malic enzyme 3
    Primary source
    TAIR:AT5G25880
    Locus tag
    AT5G25880
    See related
    Araport:AT5G25880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana NADP-malic enzyme 3; ATNADP-ME3; NADP-malic enzyme 3; T1N24.25; T1N24_25
    Summary
    The malic enzyme (EC 1.1.1.40) encoded by the ATNADP-ME3 is presumably cytosolic and restricted in its expression by both developmental and cell-specific signals.
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    Genomic context

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    See NADP-ME3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    19
    Sequence:
    Chromosome: 5; NC_003076.8 (9024334..9028395)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene indole-3-acetic acid inducible 28 Neighboring gene GA requiring 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of domains involved in the allosteric regulation of cytosolic Arabidopsis thaliana NADP-malic enzymes. Gerrard Wheeler MC, et al. FEBS J, 2009 Oct. PMID 19725876
    2. A comprehensive analysis of the NADP-malic enzyme gene family of Arabidopsis. Wheeler MC, et al. Plant Physiol, 2005 Sep. PMID 16113210, Free PMC Article
    3. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
    4. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001343951.1
    NM_001343952.1
    NM_122489.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxaloacetate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within malate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    NADP-malic enzyme 3
    NP_197960.1
    • NADP-malic enzyme 3 (NADP-ME3); FUNCTIONS IN: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity, oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor, malic enzyme activity; INVOLVED IN: N-terminal protein myristoylation, malate metabolic process, protein homooligomerization; LOCATED IN: cytosol; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Malic enzyme, NAD-binding (InterPro:IPR012302), Malic oxidoreductase (InterPro:IPR001891), Malic enzyme, conserved site (InterPro:IPR015884), Malic enzyme, N-terminal (InterPro:IPR012301), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NADP-malic enzyme 2 (TAIR:AT5G11670.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      9024334..9028395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122489.3 → NP_197960.1  NADP-malic enzyme 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197960.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XGZ0
      UniProtKB/TrEMBL
      A0A178UAR6, A0A5S9Y7H5
      Conserved Domains (1) summary
      PLN03129
      Location:20 → 588
      PLN03129; NADP-dependent malic enzyme; Provisional

    2. NM_001343952.1 → NP_001331265.1  NADP-malic enzyme 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BDF1
      Conserved Domains (1) summary
      PLN03129
      Location:20 → 461
      PLN03129; NADP-dependent malic enzyme; Provisional

    3. NM_001343951.1 → NP_001331266.1  NADP-malic enzyme 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BDG6, A0A5S9Y7H5
      Conserved Domains (1) summary
      PLN03129
      Location:20 → 560
      PLN03129; NADP-dependent malic enzyme; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XGZ0.1

    Gene LinkOut

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