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    DHAR3 dehydroascorbate reductase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831532, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DHAR3
    Official Full Name
    dehydroascorbate reductase 1
    Primary source
    TAIR:AT5G16710
    Locus tag
    AT5G16710
    See related
    Araport:AT5G16710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    dehydroascorbate reductase 1; F5E19.50; F5E19_50
    Summary
    The protein undergoes thiolation following treatment with the oxidant tert-butylhydroperoxide.
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    Genomic context

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    See DHAR3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (5483260..5485185)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene origin recognition complex subunit 3 Neighboring gene Glycosyl hydrolase superfamily protein Neighboring gene protein EMBRYO DEFECTIVE 2247 Neighboring gene caldesmon-like protein (Protein of unknown function, DUF593)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Redox regulation of ascorbate and glutathione by a chloroplastic dehydroascorbate reductase is required for high-light stress tolerance in Arabidopsis. Noshi M, et al. Biosci Biotechnol Biochem, 2016 May. PMID 26927949
    2. Cytosolic and Chloroplastic DHARs Cooperate in Oxidative Stress-Driven Activation of the Salicylic Acid Pathway. Rahantaniaina MS, et al. Plant Physiol, 2017 Jun. PMID 28381499, Free PMC Article
    3. Dehydroascorbate Reductases and Glutathione Set a Threshold for High-Light-Induced Ascorbate Accumulation. Terai Y, et al. Plant Physiol, 2020 May. PMID 32205453, Free PMC Article
    4. Functional divergence in the glutathione transferase superfamily in plants. Identification of two classes with putative functions in redox homeostasis in Arabidopsis thaliana. Dixon DP, et al. J Biol Chem, 2002 Aug 23. PMID 12077129
    5. Identification of novel seed longevity genes related to oxidative stress and seed coat by genome-wide association studies and reverse genetics. Renard J, et al. Plant Cell Environ, 2020 Oct. PMID 32519347

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121676.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glutathione dehydrogenase (ascorbate) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione dehydrogenase (ascorbate) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-ascorbic acid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within acquisition of seed longevity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ascorbate glutathione cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular oxidant detoxification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein glutathionylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    dehydroascorbate reductase 1
    NP_568336.1
    • dehydroascorbate reductase 1 (DHAR3); FUNCTIONS IN: glutathione dehydrogenase (ascorbate) activity; INVOLVED IN: protein amino acid glutathionylation; LOCATED IN: chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Glutathione S-transferase, C-terminal-like (InterPro:IPR010987), Glutathione S-transferase/chloride channel, C-terminal (InterPro:IPR017933), Glutathione S-transferase, N-terminal (InterPro:IPR004045), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: dehydroascorbate reductase 2 (TAIR:AT1G75270.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5483260..5485185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121676.4 → NP_568336.1  dehydroascorbate reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568336.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q67XJ9, Q680W2, Q8LE52, Q8VZA3, Q9FE30, Q9LFE6
      UniProtKB/TrEMBL
      A0A178UIL9, A0A5S9Y4Q2
      Conserved Domains (1) summary
      PLN02817
      Location:3 → 258
      PLN02817; glutathione dehydrogenase (ascorbate)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LE52.1

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