ACX4 acyl-CoA oxidase 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: ACX4
Official Full Name: acyl-CoA oxidase 4
Primary source: TAIR:AT3G51840
Locus tag: AT3G51840
See related: Araport:AT3G51840
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: acyl-CoA oxidase 4; ATG6; ATSCX; SHORT-CHAIN ACYL COA OXIDASE
Summary: Encodes a short-chain acyl-CoA oxidase, which catalyzes the first step of peroxisomal fatty acid beta-oxidation during early, post-germinative growth in oilseed species. Null mutants virtually lack short-chain acyl-CoA and are resistant to 2,4-dichlorophenoxybutyric acid, which is converted to the herbicide and auxin analogue 2,4-dichlorophenoxyacetic acid by beta-oxidation. Despite the almost complete loss of short-chain activity, lipid catabolism and seedling growth and establishment was unaltered in the acx4 mutant. However, double mutants in acx3acx4 (acx3 encodes medium chain acyl CoA oxidase) were not viable and arrested during embryogenesis.
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Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_115043.3

Function	Evidence Code	Pubs
enables acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables acyl-CoA oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables acyl-CoA oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables salicylic acid binding	HDA more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fatty acid beta-oxidation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within short-chain fatty acid metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in peroxisome	HDA more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

NP_190752.1

acyl-CoA oxidase 4 (ACX4); FUNCTIONS IN: oxidoreductase activity, acyl-CoA oxidase activity; INVOLVED IN: fatty acid beta-oxidation, short-chain fatty acid metabolic process, embryo development ending in seed dormancy; LOCATED IN: peroxisome; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal (InterPro:IPR013764), Acyl-CoA oxidase/dehydrogenase, type 1 (InterPro:IPR006090), Acyl-CoA dehydrogenase/oxidase (InterPro:IPR009100), Acyl-CoA dehydrogenase/oxidase, N-terminal (InterPro:IPR013786), Acyl-CoA oxidase/dehydrogenase, central domain (InterPro:IPR006091), Acyl-CoA dehydrogenase, conserved site (InterPro:IPR006089), Acyl-CoA dehydrogenase/oxidase C-terminal (InterPro:IPR009075), Acyl-CoA dehydrogenase, N-terminal (InterPro:IPR006092); BEST Arabidopsis thaliana protein match is: isovaleryl-CoA-dehydrogenase (TAIR:AT3G45300.1); Has 36828 Blast hits to 36765 proteins in 1995 species: Archae - 537; Bacteria - 24188; Metazoa - 1639; Fungi - 822; Plants - 341; Viruses - 0; Other Eukaryotes - 9301 (source: NCBI BLink).