U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    AFH14 Formin Homology 14 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840068, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    AFH14
    Official Full Name
    Formin Homology 14
    Primary source
    TAIR:AT1G31810
    Locus tag
    AT1G31810
    See related
    Araport:AT1G31810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F5M6.18; F5M6_18; Formin Homology 14
    Summary
    Encodes the Type II Arabidopsis formin14. Interacts with microtubules and microfilaments to regulate cell division.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See AFH14 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    19
    Sequence:
    Chromosome: 1; NC_003070.9 (11399607..11406809, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette 14 Neighboring gene Defensin-like (DEFL) family protein Neighboring gene oligomeric golgi complex subunit Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene cytochrome P450, family 97, subfamily A, polypeptide 3 Neighboring gene acyl-CoA-binding protein 6 Neighboring gene FRIGIDA like 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A Processive Arabidopsis Formin Modulates Actin Filament Dynamics in Association with Profilin. Zhang S, et al. Mol Plant, 2016 Jun 6. PMID 26996265
    2. The type II Arabidopsis formin14 interacts with microtubules and microfilaments to regulate cell division. Li Y, et al. Plant Cell, 2010 Aug. PMID 20709814, Free PMC Article
    3. Arabidopsis Class II Formins AtFH13 and AtFH14 Can Form Heterodimers but Exhibit Distinct Patterns of Cellular Localization. Kollárová E, et al. Int J Mol Sci, 2020 Jan 5. PMID 31948069, Free PMC Article
    4. Formin homology 2 domains occur in multiple contexts in angiosperms. Cvrcková F, et al. BMC Genomics, 2004 Jul 15. PMID 15256004, Free PMC Article
    5. Formins: intermediates in signal-transduction cascades that affect cytoskeletal reorganization. Deeks MJ, et al. Trends Plant Sci, 2002 Nov. PMID 12417149

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis Class II Formins AtFH13 and AtFH14 Can Form Heterodimers but Exhibit Distinct Patterns of Cellular Localization.
      Title: Arabidopsis Class II Formins AtFH13 and AtFH14 Can Form Heterodimers but Exhibit Distinct Patterns of Cellular Localization.
    2. AFH14 plays an important role in regulating both microtubule and microfilament arrays during cell division.
      Title: The type II Arabidopsis formin14 interacts with microtubules and microfilaments to regulate cell division.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001332980.1
    NM_102915.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within microsporogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phragmoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in preprophase band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Formin Homology 14
    NP_174461.3
    • Formin Homology 14 (AFH14); FUNCTIONS IN: microtubule binding, actin binding, actin filament binding; INVOLVED IN: microsporogenesis; LOCATED IN: preprophase band, phragmoplast, spindle; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Actin-binding FH2/DRF autoregulatory (InterPro:IPR003104), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Actin-binding FH2 (InterPro:IPR015425), Tensin phosphatase, C2 domain (InterPro:IPR014020); BEST Arabidopsis thaliana protein match is: actin binding (TAIR:AT5G07740.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      11399607..11406809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102915.4 → NP_174461.3  Formin Homology 14 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174461.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C6S1
      UniProtKB/TrEMBL
      A0A5S9WHE2
      Conserved Domains (3) summary
      pfam02181
      Location:814 → 1181
      FH2; Formin Homology 2 Domain
      pfam10409
      Location:198 → 338
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:21 → 190
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. NM_001332980.1 → NP_001321171.1  Formin Homology 14 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C6S1
      UniProtKB/TrEMBL
      A0A5S9WHE2
      Conserved Domains (3) summary
      pfam02181
      Location:814 → 1181
      FH2; Formin Homology 2 Domain
      pfam10409
      Location:198 → 338
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:21 → 190
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C6S1.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools