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    bHLH115 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841529, updated on 18-Sep-2024

    Summary

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    Official Symbol
    bHLH115
    Official Full Name
    basic helix-loop-helix (bHLH) DNA-binding superfamily protein
    Primary source
    TAIR:AT1G51070
    Locus tag
    AT1G51070
    See related
    Araport:AT1G51070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    basic Helix-Loop-Helix 115; F23H24.8; F23H24_8
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    Genomic context

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    See bHLH115 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (18927810..18929762)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene FBD-like domain family protein Neighboring gene histone H2A 10 Neighboring gene golgin family A protein Neighboring gene pseudo Neighboring gene Heavy metal transport/detoxification superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. bHLH transcription factor bHLH115 regulates iron homeostasis in Arabidopsis thaliana. Liang G, et al. J Exp Bot, 2017 Mar 1. PMID 28369511, Free PMC Article
    2. The bHLH transcription factor bHLH104 interacts with IAA-LEUCINE RESISTANT3 and modulates iron homeostasis in Arabidopsis. Zhang J, et al. Plant Cell, 2015 Mar. PMID 25794933, Free PMC Article
    3. Iron-binding E3 ligase mediates iron response in plants by targeting basic helix-loop-helix transcription factors. Selote D, et al. Plant Physiol, 2015 Jan. PMID 25452667, Free PMC Article
    4. The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots. Long TA, et al. Plant Cell, 2010 Jul. PMID 20675571, Free PMC Article
    5. The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity. Heim MA, et al. Mol Biol Evol, 2003 May. PMID 12679534

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. bHLH115 plays key roles in the maintenance of Fe homeostasis in Arabidopsis thaliana.
      Title: bHLH transcription factor bHLH115 regulates iron homeostasis in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001198263.1
    NM_103985.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    basic helix-loop-helix (bHLH) DNA-binding superfamily protein
    NP_001185192.1
    • basic Helix-Loop-Helix 115 (bHLH115); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT5G54680.1).
    NP_175518.1
    • basic Helix-Loop-Helix 115 (bHLH115); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT5G54680.1); Has 799 Blast hits to 780 proteins in 147 species: Archae - 10; Bacteria - 89; Metazoa - 90; Fungi - 16; Plants - 475; Viruses - 2; Other Eukaryotes - 117 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18927810..18929762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103985.4 → NP_175518.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175518.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C682
      UniProtKB/TrEMBL
      A0A178W1E6, A0A5S9WNE4, A0A654EMG0
      Conserved Domains (1) summary
      cd11446
      Location:71 → 146
      bHLH_AtILR3_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein IAA-leucine resistant 3 (ILR3) and similar proteins

    2. NM_001198263.1 → NP_001185192.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185192.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4I7Z3
      Conserved Domains (2) summary
      pfam00010
      Location:135 → 182
      HLH; Helix-loop-helix DNA-binding domain
      pfam06005
      Location:180 → 229
      DUF904; Protein of unknown function (DUF904)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C682.1

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