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    RPS5 Disease resistance protein (CC-NBS-LRR class) family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837775, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RPS5
    Official Full Name
    Disease resistance protein (CC-NBS-LRR class) family
    Primary source
    TAIR:AT1G12220
    Locus tag
    AT1G12220
    See related
    Araport:AT1G12220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DISEASE RESISTANCE PROTEIN RPS5; RESISTANT TO P. SYRINGAE 5; T28K15.5; T28K15_5
    Summary
    Resistance gene, mediates resistance against the bacterial pathogen Pseudomonas syringae. Contains a putative nucleotide binding site composed of kinase-1a (or P-loop), kinase-2a, and putative kinase-3a domains, 13 imperfect leucine-rich repeats, a potential leucine zipper, and two uncharacterized motifs that are well conserved in products of previously isolated R genes. Confers resistance to Pseudomonas syringae strains that express avrPphB.
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    Genomic context

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    See RPS5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (4144257..4147939)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Flavin-binding monooxygenase family protein Neighboring gene uncharacterized protein Neighboring gene RPS5-like 1 Neighboring gene Aldolase superfamily protein Neighboring gene Glycosyl hydrolases family 32 protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The long-term maintenance of a resistance polymorphism through diffuse interactions. Karasov TL, et al. Nature, 2014 Aug 28. PMID 25043057, Free PMC Article
    2. A mutation within the leucine-rich repeat domain of the Arabidopsis disease resistance gene RPS5 partially suppresses multiple bacterial and downy mildew resistance genes. Warren RF, et al. Plant Cell, 1998 Sep. PMID 9724691, Free PMC Article
    3. The TIR-NBS protein TN13 associates with the CC-NBS-LRR resistance protein RPS5 and contributes to RPS5-triggered immunity in Arabidopsis. Cai H, et al. Plant J, 2021 Aug. PMID 33982335
    4. Plastid ribosomal protein S5 is involved in photosynthesis, plant development, and cold stress tolerance in Arabidopsis. Zhang J, et al. J Exp Bot, 2016 Apr. PMID 27006483, Free PMC Article
    5. Recognition of the protein kinase AVRPPHB SUSCEPTIBLE1 by the disease resistance protein RESISTANCE TO PSEUDOMONAS SYRINGAE5 is dependent on s-acylation and an exposed loop in AVRPPHB SUSCEPTIBLE1. Qi D, et al. Plant Physiol, 2014 Jan. PMID 24225654, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The TIR-NBS protein TN13 associates with the CC-NBS-LRR resistance protein RPS5 and contributes to RPS5-triggered immunity in Arabidopsis.
      Title: The TIR-NBS protein TN13 associates with the CC-NBS-LRR resistance protein RPS5 and contributes to RPS5-triggered immunity in Arabidopsis.
    2. involved in photosynthesis, plant development, and cold stress tolerance
      Title: Plastid ribosomal protein S5 is involved in photosynthesis, plant development, and cold stress tolerance in Arabidopsis.
    3. RPS5 distinguishes PBS1 from closely related kinases based on a specific loop in the C-terminal half of PBS1.
      Title: Recognition of the protein kinase AVRPPHB SUSCEPTIBLE1 by the disease resistance protein RESISTANCE TO PSEUDOMONAS SYRINGAE5 is dependent on s-acylation and an exposed loop in AVRPPHB SUSCEPTIBLE1.
    4. the RPS5 polymorphism may not be maintained through a tightly coupled interaction involving a single coevolved R gene and effector pair; more likely, the stable polymorphism is maintained through complex and diffuse community-wide interactions
      Title: The long-term maintenance of a resistance polymorphism through diffuse interactions.
    5. Activation of RPS5 did not require PBS1 kinase function, and thus RPS5 appears to sense a subtle conformational change in PBS1, rather than cleavage.
      Title: Activation of a plant nucleotide binding-leucine rich repeat disease resistance protein by a modified self protein.
    6. The RPS5 leucine-rich repeat domain functions to suppress RPS5 activation in the absence of PBS1 cleavage and promotes RPS5 activation in its presence.
      Title: Structure-function analysis of the coiled-coil and leucine-rich repeat domains of the RPS5 disease resistance protein.
    7. RPM1, RPS2 and RPS5 are R proteins. Here, we provide evidence that FLS2 is physically associated with all three R proteins.
      Title: Physical association of pattern-triggered immunity (PTI) and effector-triggered immunity (ETI) immune receptors in Arabidopsis.
    8. The pathogenic Pseudomonas syringae effector AvrPphB cleaves the Arabidopsis receptor-like cytoplasmic kinase PBS1 to trigger cytoplasmic immune receptor RPS5-specified effector-triggered immunity (ETI).
      Title: Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001198041.2
    NM_001332024.1
    NM_101094.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nucleotide binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular anatomical structure ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Disease resistance protein (CC-NBS-LRR class) family
    NP_001184970.1
    • RESISTANT TO P. SYRINGAE 5 (RPS5); CONTAINS InterPro DOMAIN/s: Leucine-rich repeat-containing protein (InterPro:IPR015766), NB-ARC (InterPro:IPR002182), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: LRR and NB-ARC domains-containing disease resistance protein (TAIR:AT1G12280.1).
    NP_172686.1
    • RESISTANT TO P. SYRINGAE 5 (RPS5); CONTAINS InterPro DOMAIN/s: Leucine-rich repeat-containing protein (InterPro:IPR015766), NB-ARC (InterPro:IPR002182), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: LRR and NB-ARC domains-containing disease resistance protein (TAIR:AT1G12280.1); Has 17406 Blast hits to 16115 proteins in 670 species: Archae - 23; Bacteria - 856; Metazoa - 2611; Fungi - 230; Plants - 13400; Viruses - 0; Other Eukaryotes - 286 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4144257..4147939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198041.2 → NP_001184970.1  Disease resistance protein (CC-NBS-LRR class) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001184970.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64973, O81402, O82098, O82100
      UniProtKB/TrEMBL
      A0A5S9U089, Q38JZ5, Q56YM8
      Conserved Domains (4) summary
      sd00031
      Location:519 → 540
      LRR_1; leucine-rich repeat [structural motif]
      pfam00931
      Location:160 → 439
      NB-ARC; NB-ARC domain
      pfam13191
      Location:164 → 267
      AAA_16; AAA ATPase domain
      pfam13855
      Location:541 → 597
      LRR_8; Leucine rich repeat

    2. NM_101094.3 → NP_172686.1  Disease resistance protein (CC-NBS-LRR class) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172686.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64973, O81402, O82098, O82100
      UniProtKB/TrEMBL
      A0A5S9U089, Q38JZ5, Q56YM8
      Conserved Domains (4) summary
      sd00031
      Location:519 → 540
      LRR_1; leucine-rich repeat [structural motif]
      pfam00931
      Location:160 → 439
      NB-ARC; NB-ARC domain
      pfam13191
      Location:164 → 267
      AAA_16; AAA ATPase domain
      pfam13855
      Location:541 → 597
      LRR_8; Leucine rich repeat

    3. NM_001332024.1 → NP_001323155.1  Disease resistance protein (CC-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AW79, A0A5S9U089, Q38JZ5, Q38JZ6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64973.2

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