GAMMA CA2 gamma carbonic anhydrase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: GAMMA CA2
Official Full Name: gamma carbonic anhydrase 2
Primary source: TAIR:AT1G47260
Locus tag: AT1G47260
See related: Araport:AT1G47260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: APFI; F8G22.2; F8G22_2; GAMMA CARBONIC ANHYDRASE; gamma carbonic anhydrase 2
Summary: Encodes mitochondrial gamma carbonic anhydrase. Component of the NADH dehydrogenase complex.
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

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At1g47260 is required for complex I assembly and that reproductive development is dependent on the presence of complex I.
Title: Mitochondrial gamma carbonic anhydrases are required for complex I assembly and plant reproductive development.
AT1G47260 contributes to sustaining efficient photosynthesis under ambient (photorespiratory) conditions.
Title: Functional characterization of mutants affected in the carbonic anhydrase domain of the respiratory complex I in Arabidopsis thaliana.
Plant gammaCAs do not act as carbonic anhydrases but with a related activity possibly contributing to recycle CO(2) in the context of photorespiration.
Title: Recombinant plant gamma carbonic anhydrase homotrimers bind inorganic carbon.
Resuslts suggest that reduction in ROS inhibits H(2)O(2) dependent lignin polymerization in CA2 over-expressing plants, thereby causing male sterility.
Title: Ectopic expression of mitochondrial gamma carbonic anhydrase 2 causes male sterility by anther indehiscence.
At1g47260 is important for complex I assembly in plant mitochondria and respiration.
Title: Disruption of a nuclear gene encoding a mitochondrial gamma carbonic anhydrase reduces complex I and supercomplex I + III2 levels and alters mitochondrial physiology in Arabidopsis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_103620.4

Function	Evidence Code	Pubs
NOT enables carbonate dehydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables carbonate dehydratase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anther dehiscence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photorespiration	TAS Traceable Author Statement more info	PubMed
involved_in protein homotrimerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
part_of respiratory chain complex I	HDA more info	PubMed
part_of respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed

NP_175159.1

gamma carbonic anhydrase 2 (GAMMA CA2); FUNCTIONS IN: carbonate dehydratase activity; INVOLVED IN: response to salt stress, regulation of oxygen and reactive oxygen species metabolic process, anther dehiscence, photorespiration; LOCATED IN: in 6 components; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: Trimeric LpxA-like (InterPro:IPR011004); BEST Arabidopsis thaliana protein match is: gamma carbonic anhydrase 1 (TAIR:AT1G19580.1); Has 12062 Blast hits to 12006 proteins in 2273 species: Archae - 302; Bacteria - 8576; Metazoa - 53; Fungi - 108; Plants - 233; Viruses - 0; Other Eukaryotes - 2790 (source: NCBI BLink).