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    ATXRCC1 BRCT domain-containing DNA repair protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844382, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATXRCC1
    Official Full Name
    BRCT domain-containing DNA repair protein
    Primary source
    TAIR:AT1G80420
    Locus tag
    AT1G80420
    See related
    Araport:AT1G80420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    homolog of X-ray repair cross complementing 1; T21F11.25; T21F11_25; XRCC1
    Summary
    Encodes a component of plant break excision repair and functions at several stages during active DNA demethylation in Arabidopsis.
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    Genomic context

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    See ATXRCC1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (30235164..30238535, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene tetratricopeptide repeat (TPR)-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Galactose oxidase/kelch repeat superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Xrcc1-dependent and Ku-dependent DNA double-strand break repair kinetics in Arabidopsis plants. Charbonnel C, et al. Plant J, 2010 Oct. PMID 21070408
    2. The DNA repair protein XRCC1 functions in the plant DNA demethylation pathway by stimulating cytosine methylation (5-meC) excision, gap tailoring, and DNA ligation. Martínez-Macías MI, et al. J Biol Chem, 2013 Feb 22. PMID 23316050, Free PMC Article
    3. Agrobacterium T-DNA integration into the plant genome can occur without the activity of key non-homologous end-joining proteins. Park SY, et al. Plant J, 2015 Mar. PMID 25641249
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. XRCC1 is a component of plant base excision repair and functions at several stages during active DNA demethylation in Arabidopsis
      Title: The DNA repair protein XRCC1 functions in the plant DNA demethylation pathway by stimulating cytosine methylation (5-meC) excision, gap tailoring, and DNA ligation.
    2. established existence of a Ku-independent, Xrcc1-dependent double-strand breakage repair pathway
      Title: Xrcc1-dependent and Ku-dependent DNA double-strand break repair kinetics in Arabidopsis plants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084387.2
    NM_001198520.1
    NM_001334987.1
    NM_106691.4
    NM_180654.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded methylated DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA ligation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in single strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    BRCT domain-containing DNA repair protein
    NP_001077856.1
    • ATXRCC1; FUNCTIONS IN: transcription coactivator activity; INVOLVED IN: DNA repair; LOCATED IN: intracellular; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: BRCT (InterPro:IPR001357); Has 261 Blast hits to 261 proteins in 81 species: Archae - 0; Bacteria - 0; Metazoa - 156; Fungi - 25; Plants - 49; Viruses - 0; Other Eukaryotes - 31 (source: NCBI BLink).
    NP_001185449.1
    • ATXRCC1; FUNCTIONS IN: transcription coactivator activity; INVOLVED IN: DNA repair; LOCATED IN: intracellular; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: BRCT (InterPro:IPR001357).
    NP_178158.2
    • ATXRCC1; FUNCTIONS IN: transcription coactivator activity; INVOLVED IN: DNA repair; LOCATED IN: intracellular; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: BRCT (InterPro:IPR001357); Has 261 Blast hits to 261 proteins in 81 species: Archae - 0; Bacteria - 0; Metazoa - 156; Fungi - 25; Plants - 49; Viruses - 0; Other Eukaryotes - 31 (source: NCBI BLink).
    NP_850985.1
    • ATXRCC1; FUNCTIONS IN: transcription coactivator activity; INVOLVED IN: DNA repair; LOCATED IN: intracellular; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: BRCT (InterPro:IPR001357); Has 261 Blast hits to 261 proteins in 81 species: Archae - 0; Bacteria - 0; Metazoa - 156; Fungi - 25; Plants - 49; Viruses - 0; Other Eukaryotes - 31 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      30235164..30238535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198520.1 → NP_001185449.1  BRCT domain-containing DNA repair protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185449.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W516
      Conserved Domains (1) summary
      pfam00533
      Location:60 → 133
      BRCT; BRCA1 C Terminus (BRCT) domain

    2. NM_001084387.2 → NP_001077856.1  BRCT domain-containing DNA repair protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077856.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HS73, Q0WPZ1, Q24JK4, Q9FT82, Q9M8L1
      UniProtKB/TrEMBL
      A0A178W516, A0A654EQQ4
      Conserved Domains (1) summary
      cd17725
      Location:65 → 144
      BRCT_XRCC1_rpt1; First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins

    3. NM_180654.3 → NP_850985.1  BRCT domain-containing DNA repair protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850985.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HS73, Q0WPZ1, Q24JK4, Q9FT82, Q9M8L1
      UniProtKB/TrEMBL
      A0A178W516, A0A654EQQ4
      Conserved Domains (1) summary
      cd17725
      Location:65 → 144
      BRCT_XRCC1_rpt1; First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins

    4. NM_106691.4 → NP_178158.2  BRCT domain-containing DNA repair protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178158.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HS73, Q0WPZ1, Q24JK4, Q9FT82, Q9M8L1
      UniProtKB/TrEMBL
      A0A178W516, A0A654EQQ4
      Conserved Domains (1) summary
      cd17725
      Location:65 → 144
      BRCT_XRCC1_rpt1; First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins

    5. NM_001334987.1 → NP_001321272.1  BRCT domain-containing DNA repair protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HS73, Q0WPZ1, Q24JK4, Q9FT82, Q9M8L1
      UniProtKB/TrEMBL
      A0A178W516, A0A654EQQ4
      Conserved Domains (1) summary
      cd17725
      Location:65 → 144
      BRCT_XRCC1_rpt1; First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24JK4.1

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