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    FLK RNA-binding KH domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819619, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FLK
    Official Full Name
    RNA-binding KH domain-containing protein
    Primary source
    TAIR:AT3G04610
    Locus tag
    AT3G04610
    See related
    Araport:AT3G04610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F7O18.9; F7O18_9; flowering locus KH domain
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    Genomic context

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    See FLK in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (1250553..1254984, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Nucleotidylyl transferase superfamily protein Neighboring gene pseudo Neighboring gene Alba DNA/RNA-binding protein Neighboring gene WVD2-like 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The flowering time regulator FLK controls pathogen defense in Arabidopsis thaliana. Fabian M, et al. Plant Physiol, 2023 Apr 3. PMID 36662556, Free PMC Article
    2. FLK is an mRNA m(6)A reader that regulates floral transition by modulating the stability and splicing of FLC in Arabidopsis. Amara U, et al. Mol Plant, 2023 May 1. PMID 37050878
    3. Regulation of flowering time in Arabidopsis by K homology domain proteins. Mockler TC, et al. Proc Natl Acad Sci U S A, 2004 Aug 24. PMID 15310842, Free PMC Article
    4. The E3 ubiquitin ligase HOS1 regulates low ambient temperature-responsive flowering in Arabidopsis thaliana. Lee JH, et al. Plant Cell Physiol, 2012 Oct. PMID 22960247
    5. K-homology nuclear ribonucleoproteins regulate floral organ identity and determinacy in arabidopsis. Rodríguez-Cazorla E, et al. PLoS Genet, 2015 Feb. PMID 25658099, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FLK is an mRNA m[6]A reader that regulates floral transition by modulating the stability and splicing of FLC in Arabidopsis.
      Title: FLK is an mRNA m(6)A reader that regulates floral transition by modulating the stability and splicing of FLC in Arabidopsis.
    2. The flowering time regulator FLK controls pathogen defense in Arabidopsis thaliana.
      Title: The flowering time regulator FLK controls pathogen defense in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001337535.1
    NM_001337536.1
    NM_001337537.1
    NM_111333.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-binding KH domain-containing protein
    NP_187112.1
    • flowering locus KH domain (FLK); FUNCTIONS IN: RNA binding, nucleic acid binding; INVOLVED IN: positive regulation of flower development; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: K Homology, type 1, subgroup (InterPro:IPR018111), K Homology (InterPro:IPR004087), K Homology, type 1 (InterPro:IPR004088); BEST Arabidopsis thaliana protein match is: RNA-binding KH domain-containing protein (TAIR:AT4G26000.1); Has 8156 Blast hits to 5360 proteins in 381 species: Archae - 0; Bacteria - 269; Metazoa - 3587; Fungi - 776; Plants - 1209; Viruses - 216; Other Eukaryotes - 2099 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1250553..1254984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111333.5 → NP_187112.1  RNA-binding KH domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187112.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q58T16, Q9SR13
      UniProtKB/TrEMBL
      A0A178VAB5, A0A654F5G7
      Conserved Domains (2) summary
      cd00105
      Location:459 → 522
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:278 → 346
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

    2. NM_001337535.1 → NP_001325772.1  RNA-binding KH domain-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q58T16, Q9SR13
      UniProtKB/TrEMBL
      A0A178VAB5, A0A654F5G7

    3. NM_001337537.1 → NP_001325773.1  RNA-binding KH domain-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VAB5, A0A1I9LM90, A0A654F5G7

    4. NM_001337536.1 → NP_001325771.1  RNA-binding KH domain-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VAB5, A0A1I9LM90, A0A654F5G7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SR13.1

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