RACK1C_AT receptor for activated C kinase 1C [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RACK1C_AT
Official Full Name: receptor for activated C kinase 1C
Primary source: TAIR:AT3G18130
Locus tag: AT3G18130
See related: Araport:AT3G18130
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: RACK1C; receptor for activated C kinase 1C
Summary: Encodes a protein with similarity to mammalian RACKs. RACKs function to shuttle activated protein kinase C to different subcellular sites and may also function as a scaffold through physical interactions with other proteins. RACK1C has no phenotype on its own and probably acts redundantly with RACK1A and RACK1B.
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Genomic context

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See RACK1C_AT in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 2

Sequence:: Chromosome: 3; NC_003074.8 (6210878..6212551, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate the intertwined structure of a relatively small and stable protein core and the remaining regions of different levels of flexibility.
Title: Patterns of structural dynamics in RACK1 protein retained throughout evolution: a hydrogen-deuterium exchange study of three orthologs.
Receptor for activated C kinase 1C, a WD40 repeat protein, was up-regulated in the cbl1 null mutant, and two rack1c mutant lines showed decreased tolerance to salt stress, suggesting that RACK1C plays a role in salt stress resistance.
Title: Comparative proteomic analysis of the Arabidopsis cbl1 mutant in response to salt stress.
RACK1 may be required for normal production of 60S and 80S ribosomes and that its action in these processes may be regulated by abscissic acid. [RACK1C]
Title: Involvement of Arabidopsis RACK1 in protein translation and its regulation by abscisic acid.
RACK1 genes act redundantly to negatively regulate abscisic acid responses during seed germination and early seedling development
Title: RACK1 is a negative regulator of ABA responses in Arabidopsis.
An enhanced effect on ABA hypersensitivity was observed between rack1a and gpa1 or agb1 mutants in the ABA inhibition of cotyledon greening and root growth. RACK1 and AGB1 may not physically interact with each other.
Title: Dissection of the relationship between RACK1 and heterotrimeric G-proteins in Arabidopsis.
The first crystal structure of a RACK1 protein, RACK1 isoform A from Arabidopsis thaliana, at 2.4 A resolution is presented.
Title: Structure of a signal transduction regulator, RACK1, from Arabidopsis thaliana.
RACK1C (At3g18130) is functionally equivalent to RACK1A, and is positively regulated by other RACK1 genes.
Title: RACK1 genes regulate plant development with unequal genetic redundancy in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_112695.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables MAP-kinase scaffold activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to abscisic acid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within seed germination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within shoot system development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in nucleolus	HDA more info	PubMed

General protein information

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Preferred Names: receptor for activated C kinase 1C

NP_188441.1

receptor for activated C kinase 1C (RACK1C_AT); FUNCTIONS IN: nucleotide binding; INVOLVED IN: shoot development, root development; LOCATED IN: nucleolus, heterotrimeric G-protein complex; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: receptor for activated C kinase 1B (TAIR:AT1G48630.1); Has 88582 Blast hits to 37057 proteins in 965 species: Archae - 74; Bacteria - 10338; Metazoa - 34853; Fungi - 20136; Plants - 11319; Viruses - 6; Other Eukaryotes - 11856 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

6210878..6212551 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_112695.3 → NP_188441.1 receptor for activated C kinase 1C [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_188441.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LV28

UniProtKB/TrEMBL

A0A178V9J1, A0A5S9XER9

Conserved Domains (2) summary

cd00200
Location:7 → 321

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:18 → 61

7WD40; WD40 repeat [structural motif]