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    Leucine-rich repeat receptor-like protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826456, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Leucine-rich repeat receptor-like protein kinase family protein
    Primary source
    TAIR:AT4G08850
    Locus tag
    AT4G08850
    See related
    Araport:AT4G08850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T32A17.160; T32A17_160
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_003075.7 (5636479..5640952, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene pumilio 11 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Arginase/deacetylase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis leucine-rich repeat receptor-like kinase MIK2 is a crucial component of early immune responses to a fungal-derived elicitor. Coleman AD, et al. New Phytol, 2021 Mar. PMID 33253435
    2. Natural variation in rosette size under salt stress conditions corresponds to developmental differences between Arabidopsis accessions and allelic variation in the LRR-KISS gene. Julkowska MM, et al. J Exp Bot, 2016 Apr. PMID 26873976, Free PMC Article
    3. The Arabidopsis MIK2 receptor elicits immunity by sensing a conserved signature from phytocytokines and microbes. Hou S, et al. Nat Commun, 2021 Sep 17. PMID 34535661, Free PMC Article
    4. The Arabidopsis leucine-rich repeat receptor kinase MIK2/LRR-KISS connects cell wall integrity sensing, root growth and response to abiotic and biotic stresses. Van der Does D, et al. PLoS Genet, 2017 Jun. PMID 28604776, Free PMC Article
    5. Perception of a divergent family of phytocytokines by the Arabidopsis receptor kinase MIK2. Rhodes J, et al. Nat Commun, 2021 Jan 29. PMID 33514716, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis leucine-rich repeat receptor-like kinase MIK2 is a crucial component of early immune responses to a fungal-derived elicitor.
      Title: The Arabidopsis leucine-rich repeat receptor-like kinase MIK2 is a crucial component of early immune responses to a fungal-derived elicitor.
    2. Perception of a divergent family of phytocytokines by the Arabidopsis receptor kinase MIK2.
      Title: Perception of a divergent family of phytocytokines by the Arabidopsis receptor kinase MIK2.
    3. Results show MIK2 as a novel component in cell wall integrity sensing and suggest that MIK2 is a nexus linking cell wall integrity sensing to growth and environmental cues. [MIK2]
      Title: The Arabidopsis leucine-rich repeat receptor kinase MIK2/LRR-KISS connects cell wall integrity sensing, root growth and response to abiotic and biotic stresses.
    4. genome wide association study (GWAS) revealed associations with novel candidate genes for salinity tolerance such as LRR-KISS,flowering locus KH-domain containing protein and a DUF1639-containing protein. Accessions with high LRR-KISS expression developed larger rosettes under salt stress conditions.[LRR-KISS]
      Title: Natural variation in rosette size under salt stress conditions corresponds to developmental differences between Arabidopsis accessions and allelic variation in the LRR-KISS gene.
    5. MDIS1-MIK is a cell-surface receptor heteromer on the pollen tube that perceives female attractant LURE1 in A. thaliana. LURE1 specifically binds the extracellular domains of MDIS1, MIK1 and MIK2, whereas mdis1 and mik1 mik2 mutant pollen tubes respond less sensitively to LURE1. [MIK2]
      Title: A receptor heteromer mediates the male perception of female attractants in plants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_116955.5
    NM_179207.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to peptide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to insect IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect indole glucosinolate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect jasmonic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect response to herbivore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to molecule of bacterial origin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 
    located_in pollen tube IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Leucine-rich repeat receptor-like protein kinase family protein
    NP_192625.4
    • Leucine-rich repeat receptor-like protein kinase family protein; FUNCTIONS IN: kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Tyrosine-protein kinase, active site (InterPro:IPR008266), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase family protein with leucine-rich repeat domain (TAIR:AT1G35710.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_849538.2
    • Leucine-rich repeat receptor-like protein kinase family protein; FUNCTIONS IN: kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat, typical subtype (InterPro:IPR003591), Tyrosine-protein kinase, active site (InterPro:IPR008266), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: Protein kinase family protein with leucine-rich repeat domain (TAIR:AT1G35710.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      5636479..5640952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179207.3 → NP_849538.2  Leucine-rich repeat receptor-like protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849538.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DG82, Q8H7F4, Q8VZG8, Q9LCZ6
      UniProtKB/TrEMBL
      A0A178UX41, A0A5S9XQJ1, A0A654FMI7
      Conserved Domains (5) summary
      PLN00113
      Location:20 → 1035
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      cd00116
      Location:500 → 635
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:170 → 191
      LRR_RI; leucine-rich repeat [structural motif]
      pfam08263
      Location:49 → 91
      LRRNT_2; Leucine rich repeat N-terminal domain
      cl21453
      Location:781 → 1037
      PKc_like; Protein Kinases, catalytic domain

    2. NM_116955.5 → NP_192625.4  Leucine-rich repeat receptor-like protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192625.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UX41, A0A5S9XQJ1, A0A654FMI7
      Conserved Domains (5) summary
      cd00116
      Location:500 → 635
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:170 → 191
      LRR_RI; leucine-rich repeat [structural motif]
      pfam08263
      Location:49 → 91
      LRRNT_2; Leucine rich repeat N-terminal domain
      pfam13855
      Location:598 → 658
      LRR_8; Leucine rich repeat
      cl21453
      Location:781 → 949
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VZG8.3

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