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    CCD1 carotenoid cleavage dioxygenase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825527, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CCD1
    Official Full Name
    carotenoid cleavage dioxygenase 1
    Primary source
    TAIR:AT3G63520
    Locus tag
    AT3G63520
    See related
    Araport:AT3G63520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCCD1; ATNCED1; carotenoid cleavage dioxygenase 1; CAROTENOID CLEAVAGE DIOXYGENASE 1; NCED1
    Summary
    Encodes a protein with 9-<i>cis</i>-epoxycarotenoid dioxygenase activity. The enzyme was shown to act on a variety of carotenoid including beta-carotene, lutein, zeaxanthin, and all-<i>trans</i>-violaxanthin. When those compounds are used as substrates, the major reaction product detected is a C14 dialdehyde: 4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dial. The enzyme did not cleave as efficiently carotenoids containing 9-<i>cis</i>-double or allenic bonds.
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    Genomic context

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    See CCD1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Sequence:
    Chromosome: 3; NC_003074.8 (23452808..23456078)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain protein (DUF1423) Neighboring gene ncRNA Neighboring gene FMN-linked oxidoreductases superfamily protein Neighboring gene RING/U-box superfamily protein Neighboring gene thylakoid lumenal protein (Mog1/PsbP/DUF1795-like photosystem II reaction center PsbP family protein)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a unique cysteine residue proximal to the catalytic site of Arabidopsis thaliana carotenoid cleavage enzyme 1. Guo S, et al. Biochem Cell Biol, 2008 Jun. PMID 18523487
    2. The carotenase AtCCD1 from Arabidopsis thaliana is a dioxygenase. Schmidt H, et al. J Biol Chem, 2006 Apr 14. PMID 16459333
    3. Regulation of ABA level and water-stress tolerance of Arabidopsis by ectopic expression of a peanut 9-cis-epoxycarotenoid dioxygenase gene. Wan XR, et al. Biochem Biophys Res Commun, 2006 Sep 8. PMID 16870153
    4. Characterization of a novel carotenoid cleavage dioxygenase from plants. Schwartz SH, et al. J Biol Chem, 2001 Jul 6. PMID 11316814
    5. Characterization of three members of the Arabidopsis carotenoid cleavage dioxygenase family demonstrates the divergent roles of this multifunctional enzyme family. Auldridge ME, et al. Plant J, 2006 Mar. PMID 16507088

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A cysteine residue may modulate substrate affinity and (or) the reaction rate of AtCCD1.
      Title: Identification and characterization of a unique cysteine residue proximal to the catalytic site of Arabidopsis thaliana carotenoid cleavage enzyme 1.
    2. AtCCD1 from Arabidopsis thaliana is a dioxygenase
      Title: The carotenase AtCCD1 from Arabidopsis thaliana is a dioxygenase.
    3. Ectopic expression of AhNCED1 gene in 129B08/nced3 mutant Arabidopsis driven by the AtNCED3 promoter restores its ability to accumulate ABA during drought stress, and reverts its hypersensitivity to nonionic osmotic stress and soil drought.
      Title: Regulation of ABA level and water-stress tolerance of Arabidopsis by ectopic expression of a peanut 9-cis-epoxycarotenoid dioxygenase gene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_116217.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 9-cis-epoxycarotenoid dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within carotene catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within carotenoid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		  
    acts_upstream_of_or_within xanthophyll catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    carotenoid cleavage dioxygenase 1
    NP_191911.1
    • carotenoid cleavage dioxygenase 1 (CCD1); FUNCTIONS IN: 9-cis-epoxycarotenoid dioxygenase activity; INVOLVED IN: response to water deprivation, carotene catabolic process, xanthophyll catabolic process, carotenoid catabolic process; LOCATED IN: plasma membrane, vacuole, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Carotenoid oxygenase (InterPro:IPR004294); BEST Arabidopsis thaliana protein match is: nine-cis-epoxycarotenoid dioxygenase 4 (TAIR:AT4G19170.1); Has 2926 Blast hits to 2896 proteins in 500 species: Archae - 16; Bacteria - 808; Metazoa - 317; Fungi - 194; Plants - 866; Viruses - 0; Other Eukaryotes - 725 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      23452808..23456078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116217.3 → NP_191911.1  carotenoid cleavage dioxygenase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191911.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65572, Q8GRI2, Q9LY63
      UniProtKB/TrEMBL
      A0A178V6B6, A0A5S9XQ59
      Conserved Domains (1) summary
      PLN02491
      Location:1 → 538
      PLN02491; carotenoid 9,10(9',10')-cleavage dioxygenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65572.2

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