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    SIR sulfite reductase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830336, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SIR
    Official Full Name
    sulfite reductase
    Primary source
    TAIR:AT5G04590
    Locus tag
    AT5G04590
    See related
    Araport:AT5G04590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    sulfite reductase; SULFITE REDUCTASE; T1E3.2
    Summary
    A.thaliana gene encoding sulfite reductase.
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    Genomic context

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    See SIR in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (1319074..1323364)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene type-1 restriction enzyme mjaxp r protein (DUF668) Neighboring gene HhH-GPD base excision DNA repair family protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene biotin F

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sulfite reductase defines a newly discovered bottleneck for assimilatory sulfate reduction and is essential for growth and development in Arabidopsis thaliana. Khan MS, et al. Plant Cell, 2010 Apr. PMID 20424176, Free PMC Article
    2. Isolation and characterization of a gene for assimilatory sulfite reductase from Arabidopsis thaliana. Bork C, et al. Gene, 1998 May 28. PMID 9661674
    3. Sulfite reductase protects plants against sulfite toxicity. Yarmolinsky D, et al. Plant Physiol, 2013 Feb. PMID 23221833, Free PMC Article
    4. The chloroplast lumen and stromal proteomes of Arabidopsis thaliana show differential sensitivity to short- and long-term exposure to low temperature. Goulas E, et al. Plant J, 2006 Sep. PMID 16923014
    5. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate a rapid up-regulation of sulfite reductase (SiR) transcript and activity within 30 min of sulfite injection into Arabidopsis and tomato leaves.
      Title: Sulfite reductase protects plants against sulfite toxicity.
    2. SiR is essential for normal growth. Downregulation causes severe adaptive reactions of primary and secondary metabolism.
      Title: Sulfite reductase defines a newly discovered bottleneck for assimilatory sulfate reduction and is essential for growth and development in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_120541.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables copper ion binding HDA PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfite reductase (ferredoxin) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sulfite reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within sulfate assimilation TAS
    Traceable Author Statement
    more info
    		  
    involved_in sulfide oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within sulfur compound metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast nucleoid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plastid TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in stromule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sulfite reductase
    NP_196079.1
    • sulfite reductase (SIR); FUNCTIONS IN: sulfite reductase activity, sulfite reductase (ferredoxin) activity, copper ion binding; INVOLVED IN: sulfate reduction, response to salt stress, response to cold; LOCATED IN: in 7 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Sulphite reductase, ferredoxin dependent (InterPro:IPR011787), Nitrite/sulphite reductase iron-sulphur/siroheam-binding site (InterPro:IPR006066), Nitrite/sulphite reductase 4Fe-4S domain (InterPro:IPR006067), Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like (InterPro:IPR005117); BEST Arabidopsis thaliana protein match is: nitrite reductase 1 (TAIR:AT2G15620.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      1319074..1323364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120541.4 → NP_196079.1  sulfite reductase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196079.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23650, Q0WMF4, Q42590, Q94AB9, Q9LZ66
      UniProtKB/TrEMBL
      A0A178UPZ1, A0A5S9Y232, A0A654FY85
      Conserved Domains (1) summary
      PLN00178
      Location:24 → 642
      PLN00178; sulfite reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LZ66.1

    Gene LinkOut

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