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    ZTL Galactose oxidase/kelch repeat superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835842, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ZTL
    Official Full Name
    Galactose oxidase/kelch repeat superfamily protein
    Primary source
    TAIR:AT5G57360
    Locus tag
    AT5G57360
    See related
    Araport:AT5G57360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ADAGIO 1; ADO1; FKF1-LIKE PROTEIN 2; FKL2; LKP1; LOV KELCH PROTEIN 1; MSF19.2; MSF19_2; ZEITLUPE
    Summary
    Encodes clock-associated PAS protein ZTL; Also known as FKF1-like protein 2 or ADAGIO1(ADO1). A protein containing a PAS domain ZTL contributes to the plant fitness (carbon fixation, biomass) by influencing the circadian clock period. ZTL is the F-box component of an SCF complex implicated in the degradation of TOC1.
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    Genomic context

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    See ZTL in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (23241320..23244590)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ras guanine nucleotide exchange factor Q-like protein Neighboring gene uncharacterized protein Neighboring gene H[+]-ATPase 3 Neighboring gene U4/U6.U5 small nuclear ribonucleoprotein Neighboring gene Fibronectin type III domain-containing protein Neighboring gene AINTEGUMENTA-like 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ZEITLUPE encodes a novel clock-associated PAS protein from Arabidopsis. Somers DE, et al. Cell, 2000 Apr 28. PMID 10847686
    2. LKP1 (LOV kelch protein 1): a factor involved in the regulation of flowering time in arabidopsis. Kiyosue T, et al. Plant J, 2000 Sep. PMID 10998191
    3. Protein quality control is essential for the circadian clock in plants. Gil KE, et al. Plant Signal Behav, 2017 Dec 2. PMID 29172942, Free PMC Article
    4. ZEITLUPE Contributes to a Thermoresponsive Protein Quality Control System in Arabidopsis. Gil KE, et al. Plant Cell, 2017 Nov. PMID 29061867, Free PMC Article
    5. Kinetics of the LOV domain of ZEITLUPE determine its circadian function in Arabidopsis. Pudasaini A, et al. Elife, 2017 Feb 28. PMID 28244872, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZTL regulates thermomorphogenesis through TOC1 and PRR5.
      Title: ZTL regulates thermomorphogenesis through TOC1 and PRR5.
    2. ZEITLUPE enhances expression of PIF4 and YUC8 in the upper aerial parts of Arabidopsis seedlings to positively regulate hypocotyl elongation.
      Title: ZEITLUPE enhances expression of PIF4 and YUC8 in the upper aerial parts of Arabidopsis seedlings to positively regulate hypocotyl elongation.
    3. Compensatory Mutations in GI and ZTL May Modulate Temperature Compensation in the Circadian Clock.
      Title: Compensatory Mutations in GI and ZTL May Modulate Temperature Compensation in the Circadian Clock.
    4. GI plays a pivotal role in CO stability for the precise control of flowering by coordinating balanced functional properties of FKF1 and ZTL.
      Title: GIGANTEA Regulates the Timing Stabilization of CONSTANS by Altering the Interaction between FKF1 and ZEITLUPE.
    5. ZTL interacts directly with CHE and can mediate CHE ubiquitylation.ZTL role in the circadian clock and flowering.
      Title: Decoys Untangle Complicated Redundancy and Reveal Targets of Circadian Clock F-Box Proteins.
    6. the potential roles of ZTL in thermal responses and stability of the circadian clock in plants, are reported.
      Title: Protein quality control is essential for the circadian clock in plants.
    7. Data suggest that ZEITLUPE (ZTL) E3 ubiquitin ligase-mediated protein quality control contributes to the thermal stability of the circadian clock.
      Title: ZEITLUPE Contributes to a Thermoresponsive Protein Quality Control System in Arabidopsis.
    8. Suc sustains rhythms in the dark by stabilizing GI protein, dependent on the F-box protein ZEITLUPE, and implicate CONSTITUTIVE TRIPLE RESPONSE1 (CTR1), a negative regulator of ethylene signaling.
      Title: Sucrose and Ethylene Signaling Interact to Modulate the Circadian Clock.
    9. The results reveal that ZTL complexes with circadian clock proteins independent of light, but dictates enhanced protein degradation in the dark.
      Title: Kinetics of the LOV domain of ZEITLUPE determine its circadian function in Arabidopsis.
    10. GIGANTEA forms a ternary complex with HSP90 and ZEITLUPE and its co-chaperone action synergistically enhances HSP90/HSP70 maturation of ZEITLUPE in vitro.
      Title: GIGANTEA is a co-chaperone which facilitates maturation of ZEITLUPE in the Arabidopsis circadian clock.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001161311.1
    NM_125119.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables blue light photoreceptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within circadian rhythm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within entrainment of circadian clock by photoperiod IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to red light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Galactose oxidase/kelch repeat superfamily protein
    NP_001154783.1
    • ZEITLUPE (ZTL); CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), Kelch repeat type 1 (InterPro:IPR006652), Galactose oxidase/kelch, beta-propeller (InterPro:IPR011043), PAS fold (InterPro:IPR013767), Kelch repeat type 2 (InterPro:IPR011498), PAS (InterPro:IPR000014), Kelch-type beta propeller (InterPro:IPR015915); BEST Arabidopsis thaliana protein match is: LOV KELCH protein 2 (TAIR:AT2G18915.2); Has 8358 Blast hits to 5610 proteins in 807 species: Archae - 89; Bacteria - 2025; Metazoa - 1889; Fungi - 901; Plants - 2129; Viruses - 0; Other Eukaryotes - 1325 (source: NCBI BLink).
    NP_568855.1
    • ZEITLUPE (ZTL); CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), Galactose oxidase/kelch, beta-propeller (InterPro:IPR011043), Kelch repeat type 1 (InterPro:IPR006652), PAS fold (InterPro:IPR013767), PAS (InterPro:IPR000014), Kelch repeat type 2 (InterPro:IPR011498), Kelch-type beta propeller (InterPro:IPR015915); BEST Arabidopsis thaliana protein match is: LOV KELCH protein 2 (TAIR:AT2G18915.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23241320..23244590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125119.4 → NP_568855.1  Galactose oxidase/kelch repeat superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568855.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94BT6, Q9LDF6
      UniProtKB/TrEMBL
      A0A178UDC5, A0A5S9YH69
      Conserved Domains (6) summary
      PLN02193
      Location:280 → 415
      PLN02193; nitrile-specifier protein
      PRK13558
      Location:40 → 161
      PRK13558; bacterio-opsin activator; Provisional
      sd00038
      Location:293 → 341
      Kelch; KELCH repeat [structural motif]
      pfam07646
      Location:450 → 499
      Kelch_2; Kelch motif
      pfam12937
      Location:202 → 242
      F-box-like
      pfam13418
      Location:293 → 343
      Kelch_4; Galactose oxidase, central domain

    2. NM_001161311.1 → NP_001154783.1  Galactose oxidase/kelch repeat superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154783.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4KAN2
      Conserved Domains (6) summary
      cd00130
      Location:43 → 153
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      sd00038
      Location:293 → 341
      Kelch; KELCH repeat [structural motif]
      pfam07646
      Location:450 → 499
      Kelch_2; Kelch motif
      pfam12937
      Location:205 → 244
      F-box-like; F-box-like
      pfam13415
      Location:355 → 403
      Kelch_3; Galactose oxidase, central domain
      pfam13426
      Location:44 → 161
      PAS_9; PAS domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94BT6.2

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