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    CYCA2;1 cyclin a2;1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832610, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYCA2;1
    Official Full Name
    cyclin a2;1
    Primary source
    TAIR:AT5G25380
    Locus tag
    AT5G25380
    See related
    Araport:AT5G25380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cyclin a2;1; F18G18.15; F18G18_15
    Summary
    core cell cycle genes
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    Genomic context

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    See CYCA2;1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (8814517..8817887)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene phospholipase D alpha 3 Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene Nucleotide-sugar transporter family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SAMBA, a plant-specific anaphase-promoting complex/cyclosome regulator is involved in early development and A-type cyclin stabilization. Eloy NB, et al. Proc Natl Acad Sci U S A, 2012 Aug 21. PMID 22869741, Free PMC Article
    2. Transcriptional control of early vein expression of CYCA2; 1 and CYCA2;4 in Arabidopsis leaves. Donner TJ, et al. Mech Dev, 2013 Jan. PMID 22842098
    3. Increased level of polyploidy1, a conserved repressor of CYCLINA2 transcription, controls endoreduplication in Arabidopsis. Yoshizumi T, et al. Plant Cell, 2006 Oct. PMID 17012601, Free PMC Article
    4. Developmental regulation of CYCA2s contributes to tissue-specific proliferation in Arabidopsis. Vanneste S, et al. EMBO J, 2011 Jul 19. PMID 21772250, Free PMC Article
    5. Functional modules in the Arabidopsis core cell cycle binary protein-protein interaction network. Boruc J, et al. Plant Cell, 2010 Apr. PMID 20407024, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We show that stage-specific expression of CYCA2;1 and CYCA2;4 in vein development depends on regulatory elements containing, respectively, one and three evolutionarily conserved transcription-factor binding sites
      Title: Transcriptional control of early vein expression of CYCA2; 1 and CYCA2;4 in Arabidopsis leaves.
    2. SAMBA regulates cell proliferation during early development by targeting CYCLIN A2 for APC/C-mediated proteolysis
      Title: SAMBA, a plant-specific anaphase-promoting complex/cyclosome regulator is involved in early development and A-type cyclin stabilization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001343923.1
    NM_001343925.1
    NM_122447.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitotic prophase IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem or xylem histogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cyclin a2;1
    NP_001318646.1
    • cyclin a2;1 (CYCA2;1); FUNCTIONS IN: cyclin-dependent protein kinase regulator activity; INVOLVED IN: regulation of cell cycle, DNA endoreduplication; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: G2/mitotic-specific cyclin A (InterPro:IPR015453), Cyclin, C-terminal (InterPro:IPR004367), Cyclin-like (InterPro:IPR011028), Cyclin-related (InterPro:IPR013763), Cyclin, N-terminal (InterPro:IPR006671), Cyclin, A/B/D/E (InterPro:IPR014400), Cyclin (InterPro:IPR006670); BEST Arabidopsis thaliana protein match is: mitotic-like cyclin 3B from Arabidopsis (TAIR:AT5G11300.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      8814517..8817887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343924.1 → NP_001332474.1  cyclin a2;1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BH20, A0A654G4U3

    2. NM_001343923.1 → NP_001318646.1  cyclin a2;1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BH26, A0A654G4U3

    3. NM_122447.3 → NP_197920.2  cyclin a2;1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197920.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BH26, A0A654G4U3
      Conserved Domains (2) summary
      pfam00134
      Location:177 → 303
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:305 → 428
      Cyclin_C; Cyclin, C-terminal domain

    4. NM_001343925.1 → NP_001332473.1  cyclin a2;1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JWR7, Q39071, Q9ZU09
      UniProtKB/TrEMBL
      A0A654G4U3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39071.3

    Gene LinkOut

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