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    DEG14 Trypsin family protein with PDZ domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832828, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DEG14
    Official Full Name
    Trypsin family protein with PDZ domain-containing protein
    Primary source
    TAIR:AT5G27660
    Locus tag
    AT5G27660
    See related
    Araport:AT5G27660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis PARK13 homolog; AtPARK13; degradation of periplasmic proteins 14; PARK13; T1G16.1
    Summary
    Encodes a protein with similarity to human PARK13, a mitochondrial protease implicated in Parkinson disease. DEG14 is induced by heat stress and involved in degradation of misfolded proteins.
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    Genomic context

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    See DEG14 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (9789468..9792378, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene acyl-CoA binding protein 5 Neighboring gene translation initiation factor 3B1 Neighboring gene Tudor/PWWP/MBT superfamily protein Neighboring gene ncRNA Neighboring gene histone H2A 7 Neighboring gene RECQ helicase SIM

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins. Basak I, et al. J Biol Chem, 2014 May 23. PMID 24719325, Free PMC Article
    2. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that AtPARK13 (At5g27660) is a mitochondrial protease.
      Title: Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001344025.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis involved in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Trypsin family protein with PDZ domain-containing protein
    NP_001318664.1
    • Trypsin family protein with PDZ domain; FUNCTIONS IN: serine-type peptidase activity, catalytic activity, serine-type endopeptidase activity; INVOLVED IN: proteolysis; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Serine/cysteine peptidase, trypsin-like (InterPro:IPR009003), Peptidase S1C, HrtA/DegP2/Q/S (InterPro:IPR001940), Peptidase S1/S6, chymotrypsin/Hap (InterPro:IPR001254), PDZ/DHR/GLGF (InterPro:IPR001478); BEST Arabidopsis thaliana protein match is: DegP protease 1 (TAIR:AT3G27925.1); Has 16463 Blast hits to 16423 proteins in 2614 species: Archae - 115; Bacteria - 10782; Metazoa - 377; Fungi - 151; Plants - 529; Viruses - 0; Other Eukaryotes - 4509 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      9789468..9792378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001344026.1 → NP_001330700.1  Trypsin family protein with PDZ domain-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4K4D7, Q3E6S8
      UniProtKB/TrEMBL
      A0A178UPC0, A0A1P8BBM9, A0A384KP42
      Conserved Domains (1) summary
      TIGR02037
      Location:117 → 432
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

    2. NM_001344025.1 → NP_001318664.1  Trypsin family protein with PDZ domain-containing protein, partial [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4K4D7, Q3E6S8
    Nucleotide Protein
    Heading Accession and Version

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