U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    B73 molybdopterin biosynthesis CNX1 protein / molybdenum cofactor biosynthesis enzyme CNX1 (CNX1) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832224, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    B73
    Official Full Name
    molybdopterin biosynthesis CNX1 protein / molybdenum cofactor biosynthesis enzyme CNX1 (CNX1)
    Primary source
    TAIR:AT5G20990
    Locus tag
    AT5G20990
    See related
    Araport:AT5G20990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CHL6; CHLORATE RESISTANT 6; CNX; CNX1; CO-FACTOR FOR NITRATE REDUCTASE AND XANTHINE DEHYDROGENASE; CO-FACTOR FOR NITRATE REDUCTASE AND XANTHINE DEHYDROGENASE 1; MOLYBDENUM COFACTOR BIOSYNTHESIS ENZYME CNX1; SIR4; SIRTINOL 4; T10F18.20; T10F18_20
    Summary
    Involved in molybdenum cofactor (Moco) biosynthesis, inserting Mo into Molybdopterin. sir loss-of-function mutants are resistant to sirtinol, a modulator of auxin signaling.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See B73 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (7128475..7133512, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene aldehyde oxidase 1 Neighboring gene HSP20-like chaperones superfamily protein Neighboring gene ncRNA Neighboring gene methionine synthase 3 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene BTB-POZ and MATH domain 5

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molybdenum cofactor biosynthesis. The plant protein Cnx1 binds molybdopterin with high affinity. Schwarz G, et al. J Biol Chem, 1997 Oct 24. PMID 9341109
    2. Identification and biochemical characterization of molybdenum cofactor-binding proteins from Arabidopsis thaliana. Kruse T, et al. J Biol Chem, 2010 Feb 26. PMID 20040598, Free PMC Article
    3. Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis. Dai X, et al. Proc Natl Acad Sci U S A, 2005 Feb 22. PMID 15710899, Free PMC Article
    4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_001343692.1
    NM_001343693.1
    NM_122108.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molybdenum ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molybdopterin adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdopterin molybdotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		  
    acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within auxin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    molybdopterin biosynthesis CNX1 protein / molybdenum cofactor biosynthesis enzyme CNX1 (CNX1)
    NP_197599.1
    • B73; CONTAINS InterPro DOMAIN/s: Molybdenum cofactor biosynthesis, conserved site (InterPro:IPR008284), Molybdenum cofactor synthesis (InterPro:IPR020817), MoeA, N-terminal and linker domain (InterPro:IPR005110), MoeA, C-terminal, domain IV (InterPro:IPR005111), Molybdopterin binding (InterPro:IPR001453); Has 13106 Blast hits to 12710 proteins in 1951 species: Archae - 648; Bacteria - 8919; Metazoa - 385; Fungi - 192; Plants - 74; Viruses - 0; Other Eukaryotes - 2888 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7128475..7133512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122108.4 → NP_197599.1  molybdopterin biosynthesis CNX1 protein / molybdenum cofactor biosynthesis enzyme CNX1 (CNX1) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197599.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39054
      UniProtKB/TrEMBL
      A0A178U9Z9, A0A5S9Y6J3
      Conserved Domains (1) summary
      PLN02699
      Location:13 → 670
      PLN02699; Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase

    2. NM_001343692.1 → NP_001332397.1  molybdopterin biosynthesis CNX1 protein / molybdenum cofactor biosynthesis enzyme CNX1 (CNX1) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178U9Y0, A0A1P8BGU1, A0A384LMK6

    3. NM_001343693.1 → NP_001332398.1  molybdopterin biosynthesis CNX1 protein / molybdenum cofactor biosynthesis enzyme CNX1 (CNX1) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178U9Y0, A0A1P8BGU1, A0A384LMK6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39054.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools