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    thiamine diphosphate-binding fold (THDP-binding) superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830789, updated on 18-Sep-2024

    Summary

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    Official Full Name
    thiamine diphosphate-binding fold (THDP-binding) superfamily protein
    Primary source
    TAIR:AT5G09300
    Locus tag
    AT5G09300
    See related
    Araport:AT5G09300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T5E8.100; T5E8_100
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (2884179..2886880, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting-associated protein 20.2 Neighboring gene uncharacterized protein Neighboring gene Pectin lyase-like superfamily protein Neighboring gene Inositol monophosphatase family protein Neighboring gene gamma-secretase subunit Neighboring gene vacuolar sorting protein 9 domain protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Impact of the Branched-Chain Ketoacid Dehydrogenase Complex on Amino Acid Homeostasis in Arabidopsis. Peng C, et al. Plant Physiol, 2015 Nov. PMID 25986129, Free PMC Article
    2. Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis. Taylor NL, et al. Plant Physiol, 2004 Feb. PMID 14764908, Free PMC Article
    3. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_001343042.1
    NM_001343043.1
    NM_120966.4
    NM_203027.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within branched-chain amino acid catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    thiamine diphosphate-binding fold (THDP-binding) superfamily protein
    NP_568209.1
    • Thiamin diphosphate-binding fold (THDP-binding) superfamily protein; FUNCTIONS IN: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; INVOLVED IN: metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Dehydrogenase, E1 component (InterPro:IPR001017); BEST Arabidopsis thaliana protein match is: Thiamin diphosphate-binding fold (THDP-binding) superfamily protein (TAIR:AT1G21400.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_974756.1
    • Thiamin diphosphate-binding fold (THDP-binding) superfamily protein; FUNCTIONS IN: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; INVOLVED IN: metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Dehydrogenase, E1 component (InterPro:IPR001017); BEST Arabidopsis thaliana protein match is: Thiamin diphosphate-binding fold (THDP-binding) superfamily protein (TAIR:AT1G21400.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2884179..2886880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120966.4 → NP_568209.1  thiamine diphosphate-binding fold (THDP-binding) superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568209.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84JL2, Q9FY85
      UniProtKB/TrEMBL
      A0A178UAP5, A0A5S9Y2M8
      Conserved Domains (1) summary
      cd02000
      Location:133 → 425
      TPP_E1_PDC_ADC_BCADC; Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain ...

    2. NM_203027.2 → NP_974756.1  thiamine diphosphate-binding fold (THDP-binding) superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974756.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UAP5, A0A5S9Y2M8, F4KCJ8
      Conserved Domains (1) summary
      cd02000
      Location:62 → 354
      TPP_E1_PDC_ADC_BCADC; Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain ...

    3. NM_001343042.1 → NP_001331658.1  thiamine diphosphate-binding fold (THDP-binding) superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEJ4

    4. NM_001343043.1 → NP_001331657.1  thiamine diphosphate-binding fold (THDP-binding) superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEI9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84JL2.1

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