U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Ppp1r15a protein phosphatase 1, regulatory subunit 15A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171071, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ppp1r15aprovided by RGD
    Official Full Name
    protein phosphatase 1, regulatory subunit 15Aprovided by RGD
    Primary source
    RGD:621526
    See related
    AllianceGenome:RGD:621526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Peg-3; Gadd34; Myd116; RGD1624209
    Summary
    Enables protein phosphatase 1 binding activity. Involved in several processes, including cellular response to calcium ion starvation; cellular response to cordycepin; and regulation of protein metabolic process. Predicted to be located in Golgi apparatus; membrane; and mitochondrion. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in endoplasmic reticulum. Biomarker of brain ischemia and transient cerebral ischemia. Orthologous to human PPP1R15A (protein phosphatase 1 regulatory subunit 15A). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Spleen (RPKM 157.5), Heart (RPKM 149.8) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ppp1r15a in Genome Data Viewer
    Location:
    1q22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105136521..105139596, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96000053..96003128, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101511899..101515043, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene dihydrodiol dehydrogenase Neighboring gene TUB like protein 2 Neighboring gene nucleobindin 1 Neighboring gene pleckstrin homology domain containing A4 Neighboring gene transfer RNA serine (anticodon AGA) 17 Neighboring gene uncharacterized LOC120097182 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein phosphatase 1 binding PubMed 
    enables protein phosphatase 1 binding  
    enables protein phosphatase activator activity  
    enables protein phosphatase binding  
    enables protein phosphatase regulator activity  
    enables protein phosphatase regulator activity  
    Items 1 - 25 of 38
    Process Evidence Code Pubs
    involved_in apoptotic process  
    involved_in cellular response to UV PubMed 
    involved_in cellular response to antibiotic PubMed 
    involved_in cellular response to calcium ion starvation PubMed 
    involved_in cellular response to carbohydrate stimulus PubMed 
    involved_in cellular response to cordycepin PubMed 
    involved_in cellular response to desipramine PubMed 
    involved_in cellular response to gold(3+) PubMed 
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to methamphetamine hydrochloride PubMed 
    involved_in cellular response to methyl methanesulfonate PubMed 
    involved_in cellular response to organic cyclic compound PubMed 
    involved_in cellular response to xenobiotic stimulus PubMed 
    involved_in endoplasmic reticulum unfolded protein response PubMed 
    acts_upstream_of_or_within endoplasmic reticulum unfolded protein response  
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of peptidyl-threonine phosphorylation PubMed 
    involved_in negative regulation of protein processing PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of transcription by RNA polymerase I  
    involved_in protein localization to endoplasmic reticulum  
    involved_in regulation of angiogenesis PubMed 
    involved_in regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  
    involved_in regulation of translation  
    involved_in regulation of translational initiation  
    involved_in regulation of translational initiation in response to stress  
    involved_in response to cocaine PubMed 
    involved_in response to endoplasmic reticulum stress  
    involved_in response to endoplasmic reticulum stress PubMed 
    involved_in response to endoplasmic reticulum stress  
    involved_in response to environmental enrichment PubMed 
    involved_in response to immobilization stress PubMed 
    involved_in response to organic cyclic compound PubMed 
    Items 1 - 25 of 38
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in cytoplasm  
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in membrane  
    located_in mitochondrial outer membrane  
    located_in mitochondrion  
    part_of protein phosphatase type 1 complex  
    part_of protein phosphatase type 1 complex  

    General protein information

    Preferred Names
    protein phosphatase 1 regulatory subunit 15A
    Names
    growth arrest and DNA damage-inducible protein GADD34
    myeloid differentiation primary response gene 116
    myeloid differentiation primary response protein MyD116 homolog
    progression elevated gene 3 protein
    protein phosphatase 1, regulatory (inhibitor) subunit 15A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133546.3NP_598230.2  protein phosphatase 1 regulatory subunit 15A

      See identical proteins and their annotated locations for NP_598230.2

      Status: VALIDATED

      Source sequence(s)
      BC072513, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O88344, Q6IN02, Q7TQC2
      UniProtKB/TrEMBL
      A0A0G2JSW4, A6JB49
      Conserved Domains (1) summary
      pfam10488
      Location:459526
      PP1c_bdg; Phosphatase-1 catalytic subunit binding region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      105136521..105139596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.