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    Tmem237 transmembrane protein 237 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316412, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem237provided by RGD
    Official Full Name
    transmembrane protein 237provided by RGD
    Primary source
    RGD:1306705
    See related
    EnsemblRapid:ENSRNOG00000024085 AllianceGenome:RGD:1306705
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Als2cr4
    Summary
    Predicted to be involved in cilium assembly and regulation of Wnt signaling pathway. Predicted to be located in cone photoreceptor outer segment; photoreceptor connecting cilium; and rod photoreceptor outer segment. Predicted to be active in ciliary transition zone. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 14. Orthologous to human TMEM237 (transmembrane protein 237). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 55.3), Lung (RPKM 34.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem237 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (68027481..68066731, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (60533348..60569253, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65882063..65917424, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094795 Neighboring gene C2 calcium dependent domain containing 6 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene mitochondrial intermembrane space import and assembly protein 40-like Neighboring gene MAGUK p55 scaffold protein 4 Neighboring gene alsin Rho guanine nucleotide exchange factor ALS2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Deciphering the structure and function of Als2cr4 in the mouse retina. Zuniga FI, et al. Invest Ophthalmol Vis Sci, 2010 Sep. PMID 20375344, Free PMC Article
    2. TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone. Huang L, et al. Am J Hum Genet, 2011 Dec 9. PMID 22152675, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ciliary transition zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary transition zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cone photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor connecting cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in rod photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 237
    Names
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108220.1 → NP_001101690.1  transmembrane protein 237

      See identical proteins and their annotated locations for NP_001101690.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473965
      UniProtKB/TrEMBL
      A6IP94
      Conserved Domains (1) summary
      pfam15383
      Location:27 → 269
      TMEM237; Transmembrane protein 237

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      68027481..68066731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244977.5 → XP_006245039.1  transmembrane protein 237 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K7G5, A0A8I6G323
      Related
      ENSRNOP00000074197.1, ENSRNOT00000077483.3
      Conserved Domains (2) summary
      TIGR02223
      Location:19 → 245
      ftsN; cell division protein FtsN
      pfam15383
      Location:138 → 381
      TMEM237; Transmembrane protein 237

    2. XM_039083614.2 → XP_038939542.1  transmembrane protein 237 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G323
      Related
      ENSRNOP00000036108.6, ENSRNOT00000031866.6
      Conserved Domains (1) summary
      pfam15383
      Location:133 → 375
      TMEM237; Transmembrane protein 237

    3. XM_039083617.2 → XP_038939545.1  transmembrane protein 237 isoform X6

      Conserved Domains (1) summary
      pfam15383
      Location:148 → 322
      TMEM237; Transmembrane protein 237

    4. XM_006244975.5 → XP_006245037.1  transmembrane protein 237 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G323, D3ZAP8
      Conserved Domains (2) summary
      TIGR02223
      Location:29 → 255
      ftsN; cell division protein FtsN
      pfam15383
      Location:148 → 391
      TMEM237; Transmembrane protein 237

    5. XM_039083616.2 → XP_038939544.1  transmembrane protein 237 isoform X5

      Conserved Domains (1) summary
      pfam15383
      Location:148 → 303
      TMEM237; Transmembrane protein 237

    6. XM_063267179.1 → XP_063123249.1  transmembrane protein 237 isoform X4

      UniProtKB/TrEMBL
      A0A8I6G323
      Related
      ENSRNOP00000078512.2, ENSRNOT00000119394.2

    7. XM_039083615.2 → XP_038939543.1  transmembrane protein 237 isoform X5

      Conserved Domains (1) summary
      pfam15383
      Location:148 → 303
      TMEM237; Transmembrane protein 237

    8. XM_063267180.1 → XP_063123250.1  transmembrane protein 237 isoform X5

    RNA

    1. XR_005488910.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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