Arhgef16 Rho guanine nucleotide exchange factor 16 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgef16provided by RGD
Official Full Name: Rho guanine nucleotide exchange factor 16provided by RGD
Primary source: RGD:1588981
See related: EnsemblRapid:ENSRNOG00000046803 AllianceGenome:RGD:1588981
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable PDZ domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; cell chemotaxis; and positive regulation of protein localization to plasma membrane. Orthologous to human ARHGEF16 (Rho guanine nucleotide exchange factor 16). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 46.1), Lung (RPKM 20.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (170126573..170148624, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (164843656..164866212, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (171626450..171649124, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH144516 (e-PCR)
- UniSTS:233761

BI285850 (e-PCR)
- UniSTS:244913

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho guanine nucleotide exchange factor 16

Names: Rho guanine nucleotide exchange factor (GEF) 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127591.1 → NP_001121063.1 rho guanine nucleotide exchange factor 16

See identical proteins and their annotated locations for NP_001121063.1

Status: PROVISIONAL

Source sequence(s)

BC166429

UniProtKB/TrEMBL

A0A0G2K2L6, B2GUW2

Related

ENSRNOP00000066478.1, ENSRNOT00000072786.4

Conserved Domains (3) summary

cd11938
Location:633 → 684

SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26

cd01221
Location:489 → 622

PH_ephexin; Ephexin Pleckstrin homology (PH) domain

pfam00621
Location:288 → 466

RhoGEF; RhoGEF domain