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    Efcab2 EF-hand calcium binding domain 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289280, updated on 9-Dec-2024

    Summary

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    Symbol
    Efcab2provided by RGD
    Full Name
    EF-hand calcium binding domain 2provided by RGD
    Primary source
    RGD:1308593
    See related
    EnsemblRapid:ENSRNOG00000042201 AllianceGenome:RGD:1308593
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308593
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be active in sperm principal piece. Orthologous to human EFCAB2 (EF-hand calcium binding domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 28.8), Thymus (RPKM 25.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Efcab2 in Genome Data Viewer
    Location:
    13q25-q26
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (92683182..92769939)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (90152002..90237918)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (96303578..96414404)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 1 Neighboring gene kinesin family member 26B Neighboring gene uncharacterized LOC134481603

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in sperm principal piece IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dynein regulatory complex protein 8
    Names
    EF-hand calcium-binding domain-containing protein 2
    EF-hand calcium-binding domain-containing protein 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105977.1 → NP_001099447.1  dynein regulatory complex protein 8

      See identical proteins and their annotated locations for NP_001099447.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473985
      UniProtKB/TrEMBL
      A6JGE7, D3ZXJ2
      Conserved Domains (2) summary
      PTZ00183
      Location:5 → 133
      PTZ00183; centrin; Provisional
      cl08302
      Location:73 → 133
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      92683182..92769939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090537.2 → XP_038946465.1  dynein regulatory complex protein 8 isoform X16

      Conserved Domains (1) summary
      PTZ00184
      Location:22 → 129
      PTZ00184; calmodulin; Provisional

    2. XM_039090534.2 → XP_038946462.1  dynein regulatory complex protein 8 isoform X11

      UniProtKB/TrEMBL
      A0A0G2K9F5
      Conserved Domains (1) summary
      PTZ00184
      Location:22 → 175
      PTZ00184; calmodulin; Provisional

    3. XM_006250319.5 → XP_006250381.1  dynein regulatory complex protein 8 isoform X15

      UniProtKB/TrEMBL
      A0A0G2K9F5
      Conserved Domains (2) summary
      PTZ00183
      Location:5 → 159
      PTZ00183; centrin; Provisional
      cl08302
      Location:99 → 159
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    4. XM_039090549.2 → XP_038946477.1  dynein regulatory complex protein 8 isoform X28

      Conserved Domains (1) summary
      PTZ00184
      Location:22 → 103
      PTZ00184; calmodulin; Provisional

    5. XM_063272155.1 → XP_063128225.1  dynein regulatory complex protein 8 isoform X19

    6. XM_039090544.2 → XP_038946472.1  dynein regulatory complex protein 8 isoform X23

      Conserved Domains (1) summary
      COG5126
      Location:19 → 153
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    7. XM_039090538.2 → XP_038946466.1  dynein regulatory complex protein 8 isoform X17

      Conserved Domains (1) summary
      PTZ00184
      Location:12 → 158
      PTZ00184; calmodulin; Provisional

    8. XM_063272158.1 → XP_063128228.1  dynein regulatory complex protein 8 isoform X25

    9. XM_063272162.1 → XP_063128232.1  dynein regulatory complex protein 8 isoform X31

    10. XM_063272156.1 → XP_063128226.1  dynein regulatory complex protein 8 isoform X20

    11. XM_039090535.2 → XP_038946463.1  dynein regulatory complex protein 8 isoform X13

      Related
      ENSRNOP00000099910.1, ENSRNOT00000155864.1
      Conserved Domains (1) summary
      COG5126
      Location:68 → 177
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    12. XM_063272154.1 → XP_063128224.1  dynein regulatory complex protein 8 isoform X18

    13. XM_063272161.1 → XP_063128231.1  dynein regulatory complex protein 8 isoform X30

    14. XM_039090543.2 → XP_038946471.1  dynein regulatory complex protein 8 isoform X22

      Conserved Domains (1) summary
      PTZ00184
      Location:22 → 127
      PTZ00184; calmodulin; Provisional

    15. XM_063272147.1 → XP_063128217.1  dynein regulatory complex protein 8 isoform X7

    16. XM_039090545.2 → XP_038946473.1  dynein regulatory complex protein 8 isoform X24

      Conserved Domains (1) summary
      PTZ00184
      Location:22 → 127
      PTZ00184; calmodulin; Provisional

    17. XM_039090547.2 → XP_038946475.1  dynein regulatory complex protein 8 isoform X27

      Conserved Domains (1) summary
      PTZ00184
      Location:22 → 128
      PTZ00184; calmodulin; Provisional

    18. XM_063272150.1 → XP_063128220.1  dynein regulatory complex protein 8 isoform X10

    19. XM_063272157.1 → XP_063128227.1  dynein regulatory complex protein 8 isoform X21

    20. XM_063272163.1 → XP_063128233.1  dynein regulatory complex protein 8 isoform X32

    21. XM_063272153.1 → XP_063128223.1  dynein regulatory complex protein 8 isoform X14

    22. XM_063272148.1 → XP_063128218.1  dynein regulatory complex protein 8 isoform X8

    23. XM_063272159.1 → XP_063128229.1  dynein regulatory complex protein 8 isoform X26

    24. XM_063272160.1 → XP_063128230.1  dynein regulatory complex protein 8 isoform X29

    25. XM_063272142.1 → XP_063128212.1  dynein regulatory complex protein 8 isoform X4

    26. XM_063272140.1 → XP_063128210.1  dynein regulatory complex protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZXW0
      Related
      ENSRNOP00000084748.2, ENSRNOT00000109721.2

    27. XM_063272141.1 → XP_063128211.1  dynein regulatory complex protein 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZXW0
      Related
      ENSRNOP00000106408.1, ENSRNOT00000147056.1

    28. XM_063272152.1 → XP_063128222.1  dynein regulatory complex protein 8 isoform X12

    29. XM_063272146.1 → XP_063128216.1  dynein regulatory complex protein 8 isoform X6

    30. XM_063272151.1 → XP_063128221.1  dynein regulatory complex protein 8 isoform X9

    31. XM_063272143.1 → XP_063128213.1  dynein regulatory complex protein 8 isoform X5

    32. XM_063272139.1 → XP_063128209.1  dynein regulatory complex protein 8 isoform X1

    33. XM_063272144.1 → XP_063128214.1  dynein regulatory complex protein 8 isoform X6

    34. XM_063272149.1 → XP_063128219.1  dynein regulatory complex protein 8 isoform X9

    Nucleotide Protein Strain
    Heading Accession and Version

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