Dync2i2 dynein 2 intermediate chain 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dync2i2provided by RGD
Official Full Name: dynein 2 intermediate chain 2provided by RGD
Primary source: RGD:1359465
See related: EnsemblRapid:ENSRNOG00000015636 AllianceGenome:RGD:1359465
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Wdr34
Summary: Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in cilium assembly and intraciliary retrograde transport. Predicted to be located in several cellular components, including axoneme; filopodium; and microtubule organizing center. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in ciliary plasm. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 11 with or without polydactyly. Orthologous to human DYNC2I2 (dynein 2 intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 254.3), Lung (RPKM 217.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (33703882..33719960, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (13306039..13322121, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (8599251..8615329, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH133209 (e-PCR)
- UniSTS:216492

RH134500 (e-PCR)
- UniSTS:217780

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light chain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in intraciliary retrograde transport	ISO Inferred from Sequence Orthology more info
involved_in intraciliary transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
is_active_in ciliary plasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytoplasmic dynein 2 intermediate chain 2

Names: WD repeat domain 34; WD repeat-containing protein 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005542.2 → NP_001005542.2 cytoplasmic dynein 2 intermediate chain 2

Status: VALIDATED

Source sequence(s)

BC082103, JAXUCZ010000003

UniProtKB/TrEMBL

A0A0G2QC64, A0A8I6AC17

Related

ENSRNOP00000021132.6, ENSRNOT00000021132.8

Conserved Domains (2) summary

COG2319
Location:101 → 515

WD40; WD40 repeat [General function prediction only]

sd00039
Location:223 → 265

7WD40; WD40 repeat [structural motif]