Bccip BRCA2 and CDKN1A interacting protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bccipprovided by RGD
Official Full Name: BRCA2 and CDKN1A interacting proteinprovided by RGD
Primary source: RGD:1307362
See related: EnsemblRapid:ENSRNOG00000018066 AllianceGenome:RGD:1307362
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable kinase regulator activity and tubulin binding activity. Predicted to be involved in DNA damage response; microtubule cytoskeleton organization; and neuroendocrine cell differentiation. Predicted to act upstream of or within regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be located in cytosol; microtubule cytoskeleton; and nucleoplasm. Predicted to be part of nuclear cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Orthologous to human BCCIP (BRCA2 and CDKN1A interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 168.7), Heart (RPKM 134.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (197942535..197954948)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (188512544..188524957)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (205777474..205789887)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in neuroendocrine cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
part_of nuclear cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: BRCA2 and CDKN1A-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.