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    Gabrr2 gamma-aminobutyric acid type A receptor subunit rho 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29695, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gabrr2provided by RGD
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit rho 2provided by RGD
    Primary source
    RGD:61902
    See related
    EnsemblRapid:ENSRNOG00000007490 AllianceGenome:RGD:61902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GABA-A receptor activity; protein domain specific binding activity; and transmitter-gated monoatomic ion channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to act upstream of or within gamma-aminobutyric acid signaling pathway and visual perception. Is active in GABA-ergic synapse. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human GABRR2 (gamma-aminobutyric acid type A receptor subunit rho2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 17.2), Muscle (RPKM 15.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gabrr2 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (52242564..52286255)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (47445280..47489929)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (48303366..48341571)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2, J1 Neighboring gene ribonuclease P/MRP subunit p38, pseudogene 1 Neighboring gene uncharacterized LOC120102852 Neighboring gene uncharacterized LOC102555980 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho 1 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evidence for a functional role of GABA receptors in the rat mature hippocampus. Alakuijala A, et al. Eur J Neurosci, 2006 Jan. PMID 16420458
    2. Identification of GABAA receptor subunits in rat retina: cloning of the rat GABAA receptor rho 2-subunit cDNA. Ogurusu T, et al. J Neurochem, 1995 Sep. PMID 7643126
    3. GABAB receptor subunits, R1 and R2, in brainstem catecholamine and serotonin neurons. Burman KJ, et al. Brain Res, 2003 Apr 25. PMID 12706246
    4. gamma-Aminobutyric acidA rho receptor subunits in the developing rat hippocampus. Didelon F, et al. J Neurosci Res, 2002 Mar 15. PMID 11891787
    5. Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block. Zhang D, et al. Proc Natl Acad Sci U S A, 1995 Dec 5. PMID 8524843, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The expression of GABA(C) receptors in the cerebellum adds a new dimension to the regulation of GABAergic neurotransmission
      Title: Expression of GABArho subunits during rat cerebellum development.
    2. The rho1 and rho2 products appeared to be developmentally regulated; they were found to be more pronounced in adulthood.
      Title: gamma-Aminobutyric acidA rho receptor subunits in the developing rat hippocampus.
    3. GABA(C) receptors are specifically involved in aspects of visual image motion processing in the rat brain.
      Title: GABA receptor rho subunit expression in the developing rat brain.
    4. The proportion of neurons in the brainstem with immunoreactivity for the GABA(B)R2 subunit included catecholamine and serotonin neurons.
      Title: GABAB receptor subunits, R1 and R2, in brainstem catecholamine and serotonin neurons.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GABA-A receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GABA-A receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GABA-A receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GABA-gated chloride ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables inhibitory extracellular ligand-gated monoatomic ion channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT acts_upstream_of_or_within eye photoreceptor cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within visual perception ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in GABA-ergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-aminobutyric acid receptor subunit rho-2
    Names
    GABA(A) receptor subunit rho-2
    GABA(C) receptor
    GABAAR subunit rho-2
    gamma-aminobutyric acid (GABA) A receptor, rho 2
    gamma-aminobutyric acid (GABA) receptor, rho 2
    gamma-aminobutyric acid (GABA-A) receptor, subunit rho 2
    gamma-aminobutyric acid (GABA-C) receptor, subunit rho 2
    gamma-aminobutyric acid A receptor, rho 2
    gamma-aminobutyric acid type A receptor rho 2 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017292.2 → NP_058988.1  gamma-aminobutyric acid receptor subunit rho-2 precursor

      See identical proteins and their annotated locations for NP_058988.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P47742
      UniProtKB/TrEMBL
      A6IIK8
      Related
      ENSRNOP00000110953.1, ENSRNOT00000130265.1
      Conserved Domains (3) summary
      TIGR00860
      Location:61 → 464
      LIC; Cation transporter family protein
      cd03558
      Location:178 → 192
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:76 → 261
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      52242564..52286255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109380.2 → XP_038965308.1  gamma-aminobutyric acid receptor subunit rho-2 isoform X1

      UniProtKB/TrEMBL
      A6IIK8
      Related
      ENSRNOP00000100074.1, ENSRNOT00000155034.1
      Conserved Domains (2) summary
      TIGR00860
      Location:87 → 490
      LIC; Cation transporter family protein
      cd19005
      Location:102 → 287
      LGIC_ECD_GABAAR_rho; extracellular domain of gamma-aminobutyric acid receptor subunit rho

    2. XM_039109382.2 → XP_038965310.1  gamma-aminobutyric acid receptor subunit rho-2 isoform X3

      UniProtKB/TrEMBL
      A6IIK8
      Conserved Domains (3) summary
      TIGR00860
      Location:39 → 442
      LIC; Cation transporter family protein
      cd03558
      Location:156 → 170
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:54 → 239
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

    3. XM_039109385.2 → XP_038965313.1  gamma-aminobutyric acid receptor subunit rho-2 isoform X7

      Conserved Domains (1) summary
      TIGR00860
      Location:1 → 308
      LIC; Cation transporter family protein

    4. XM_039109381.2 → XP_038965309.1  gamma-aminobutyric acid receptor subunit rho-2 isoform X2

      Conserved Domains (2) summary
      cd19005
      Location:102 → 287
      LGIC_ECD_GABAAR_rho; extracellular domain of gamma-aminobutyric acid receptor subunit rho
      cd19059
      Location:288 → 376
      LGIC_TM_GABAAR_rho; transmembrane domain of rho subunits of type-A gamma-aminobutyric acid receptor (GABAAR)

    5. XM_039109384.2 → XP_038965312.1  gamma-aminobutyric acid receptor subunit rho-2 isoform X6

      Conserved Domains (3) summary
      cd19005
      Location:102 → 287
      LGIC_ECD_GABAAR_rho; extracellular domain of gamma-aminobutyric acid receptor subunit rho
      cd03559
      Location:289 → 312
      LGIC_TM; TM1 helix [structural motif]
      cl38911
      Location:288 → 323
      LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels

    6. XM_008763611.4 → XP_008761833.1  gamma-aminobutyric acid receptor subunit rho-2 isoform X4

      UniProtKB/TrEMBL
      A6IIK8
      Conserved Domains (2) summary
      pfam02931
      Location:24 → 214
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:221 → 414
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    7. XM_063287266.1 → XP_063143336.1  gamma-aminobutyric acid receptor subunit rho-2 isoform X7

    8. XM_039109383.1 → XP_038965311.1  gamma-aminobutyric acid receptor subunit rho-2 isoform X5

      Conserved Domains (3) summary
      TIGR00860
      Location:2 → 365
      LIC; Cation transporter family protein
      cd03558
      Location:79 → 93
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:1 → 162
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47742.3 GenPept UniProtKB/Swiss-Prot:P47742

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