Tpp1 tripeptidyl peptidase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tpp1provided by RGD
Official Full Name: tripeptidyl peptidase 1provided by RGD
Primary source: RGD:621296
See related: EnsemblRapid:ENSRNOG00000019212 AllianceGenome:RGD:621296
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cln2
Summary: Enables endopeptidase activity; peptide binding activity; and tripeptidyl-peptidase activity. Involved in protein catabolic process. Predicted to be located in several cellular components, including lysosome; membrane raft; and recycling endosome. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 7 and neuronal ceroid lipofuscinosis 2. Orthologous to human TPP1 (tripeptidyl peptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 381.6), Spleen (RPKM 255.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (169509816..169515939, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (160097984..160104108, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (170588036..170594159, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport.
Title: A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport.
TPPI activity was strictly regulated following hypoxic stress in the rat brain.
Title: Effect of acute hypoxic shock on the rat brain morphology and tripeptidyl peptidase I activity.
These findings also suggest that TPP I is involved in the general turnover of chemotransmitters between glomus cells and sensory nerve endings which emphasizes its importance for chemoreception under hypoxic conditions.
Title: Histochemical demonstration of tripeptidyl aminopeptidase I in the rat carotid body.
We describe a molecular mechanism in which inducible interactions of noncanonical RNA motif structures with targeting factor heterogeneous nuclear ribonucleoprotein (hnRNP) A2 form the basis for activity-dependent dendritic RNA targeting with CLN2.
Title: Interactions of noncanonical motifs with hnRNP A2 promote activity-dependent RNA transport in neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

AW107731 (e-PCR)
- UniSTS:208175

PCDH16_1801 (e-PCR)
- UniSTS:280891

UniSTS:496054 (e-PCR)
- UniSTS:496054

Tpp1 (e-PCR), detects polymorphism
- UniSTS:496054

D1Bda72 (e-PCR)
- UniSTS:239823

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables lysophosphatidic acid binding	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables sulfatide binding	IEA Inferred from Electronic Annotation more info
enables sulfatide binding	ISO Inferred from Sequence Orthology more info
enables sulfatide binding	ISS Inferred from Sequence or Structural Similarity more info
enables tripeptidyl-peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tripeptidyl-peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables tripeptidyl-peptidase activity	IEA Inferred from Electronic Annotation more info
enables tripeptidyl-peptidase activity	ISO Inferred from Sequence Orthology more info
enables tripeptidyl-peptidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in bone resorption	IEA Inferred from Electronic Annotation more info
involved_in bone resorption	ISO Inferred from Sequence Orthology more info
involved_in bone resorption	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in lysosomal protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lysosomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lysosome organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in neuromuscular process controlling balance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
involved_in peptide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in peptide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptide catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
involved_in protein localization to chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tripeptidyl-peptidase 1

Names: TPP-1; TPP-I; ceroid-lipofuscinosis, neuronal 2; tripeptidyl aminopeptidase; tripeptidyl-peptidase I

NP_112647.2

EC 3.4.14.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031357.2 → NP_112647.2 tripeptidyl-peptidase 1 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q9EQV6

UniProtKB/TrEMBL

Q642E6

Related

ENSRNOP00000026280.4, ENSRNOT00000026280.6

Conserved Domains (2) summary

cd04056
Location:199 → 557

Peptidases_S53; Peptidase domain in the S53 family

cd11377
Location:34 → 173

Pro-peptidase_S53; Activation domain of S53 peptidases