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    Zmym2 zinc finger MYM-type containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305913, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zmym2provided by RGD
    Official Full Name
    zinc finger MYM-type containing 2provided by RGD
    Primary source
    RGD:1593255
    See related
    EnsemblRapid:ENSRNOG00000008734 AllianceGenome:RGD:1593255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in PML body. Orthologous to human ZMYM2 (zinc finger MYM-type containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 188.7), Brain (RPKM 175.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zmym2 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (35151356..35224528)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (31035835..31108945)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (37156250..37229803)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) 64 Neighboring gene RAN guanine nucleotide release factor, pseudogene 4 Neighboring gene Myb/SANT DNA binding domain containing 5, pseudogene 1 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ZNF198, a zinc finger protein rearranged in myeloproliferative disease, localizes to the PML nuclear bodies and interacts with SUMO-1 and PML. Kunapuli P, et al. Exp Cell Res, 2006 Nov 15. PMID 17027752
    2. ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins. Kunapuli P, et al. Oncogene, 2003 May 29. PMID 12776193
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger MYM-type protein 2
    Names
    zinc finger, MYM-type 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399496.1 → NP_001386425.1  zinc finger MYM-type protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6AEP0
      Related
      ENSRNOP00000103363.1, ENSRNOT00000161010.1
      Conserved Domains (2) summary
      pfam06467
      Location:461 → 501
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1191 → 1359
      DUF3504; Domain of unknown function (DUF3504)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      35151356..35224528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274265.1 → XP_063130335.1  zinc finger MYM-type protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AEP0

    2. XM_063274263.1 → XP_063130333.1  zinc finger MYM-type protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEP0

    3. XM_063274264.1 → XP_063130334.1  zinc finger MYM-type protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEP0

    4. XM_039093864.2 → XP_038949792.1  zinc finger MYM-type protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEP0
      Conserved Domains (2) summary
      pfam06467
      Location:461 → 501
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1191 → 1359
      DUF3504; Domain of unknown function (DUF3504)

    5. XM_039093866.2 → XP_038949794.1  zinc finger MYM-type protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AEP0
      Related
      ENSRNOP00000090897.2, ENSRNOT00000109069.2
      Conserved Domains (2) summary
      pfam06467
      Location:461 → 501
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1189 → 1357
      DUF3504; Domain of unknown function (DUF3504)

    6. XM_039093867.2 → XP_038949795.1  zinc finger MYM-type protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AEP0
      Conserved Domains (2) summary
      pfam06467
      Location:461 → 501
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1078 → 1246
      DUF3504; Domain of unknown function (DUF3504)
    Nucleotide Protein Strain
    Heading Accession and Version

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