U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    NRT2:1 nitrate transporter 2:1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837327, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    NRT2:1
    Official Full Name
    nitrate transporter 2:1
    Primary source
    TAIR:AT1G08090
    Locus tag
    AT1G08090
    See related
    Araport:AT1G08090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACH1; ATNRT2.1; ATNRT2:1; LATERAL ROOT INITIATION 1; LIN1; NITRATE TRANSPORTER 1; NITRATE TRANSPORTER 2; NITRATE TRANSPORTER 2.1; nitrate transporter 2:1; NRT2; NRT2.1; NRT2;1AT; T6D22.17; T6D22_17; TRANS-MEMBRANE NITRATE TRANSPORTER PROTEIN ATNRT2:1
    Summary
    High-affinity nitrate transporter. Up-regulated by nitrate. Functions as a repressor of lateral root initiation independently of nitrate uptake.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See NRT2:1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (2524023..2526322)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene alpha carbonic anhydrase 7 Neighboring gene nitrate transporter 2.2 Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Transcription factor module NLP-NIGT1 fine-tunes NITRATE TRANSPORTER2.1 expression. Ueda Y, et al. Plant Physiol, 2023 Nov 22. PMID 37595050, Free PMC Article
    2. An arabidopsis T-DNA mutant affected in Nrt2 genes is impaired in nitrate uptake. Filleur S, et al. FEBS Lett, 2001 Feb 2. PMID 11165253
    3. The putative high-affinity nitrate transporter NRT2.1 represses lateral root initiation in response to nutritional cues. Little DY, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157886, Free PMC Article
    4. Regulation of root nitrate uptake at the NRT2.1 protein level in Arabidopsis thaliana. Wirth J, et al. J Biol Chem, 2007 Aug 10. PMID 17573350
    5. The Arabidopsis nitrate transporter AtNRT2.1 is targeted to the root plasma membrane. Chopin F, et al. Plant Physiol Biochem, 2007 Aug. PMID 17583518

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphoregulation in the N-terminus of NRT2.1 affects nitrate uptake by controlling the interaction of NRT2.1 with NAR2.1 and kinase HPCAL1 in Arabidopsis.
      Title: Phosphoregulation in the N-terminus of NRT2.1 affects nitrate uptake by controlling the interaction of NRT2.1 with NAR2.1 and kinase HPCAL1 in Arabidopsis.
    2. Transcription factor module NLP-NIGT1 fine-tunes NITRATE TRANSPORTER2.1 expression.
      Title: Transcription factor module NLP-NIGT1 fine-tunes NITRATE TRANSPORTER2.1 expression.
    3. Brassinosteroid transcription factor BES1 modulates nitrate deficiency by promoting NRT2.1 and NRT2.2 transcription in Arabidopsis.
      Title: Brassinosteroid transcription factor BES1 modulates nitrate deficiency by promoting NRT2.1 and NRT2.2 transcription in Arabidopsis.
    4. The nitrate transporter NRT2.1 directly antagonizes PIN7-mediated auxin transport for root growth adaptation.
      Title: The nitrate transporter NRT2.1 directly antagonizes PIN7-mediated auxin transport for root growth adaptation.
    5. NRT2.1 C-terminus phosphorylation prevents root high affinity nitrate uptake activity in Arabidopsis thaliana.
      Title: NRT2.1 C-terminus phosphorylation prevents root high affinity nitrate uptake activity in Arabidopsis thaliana.
    6. Phosphorylation at Ser28 stabilizes the Arabidopsis nitrate transporter NRT2.1 in response to nitrate limitation.
      Title: Phosphorylation at Ser28 stabilizes the Arabidopsis nitrate transporter NRT2.1 in response to nitrate limitation.
    7. Phloem-specific polypeptides that are induced in leaves upon perception of root-derived CEP act as descending long-distance mobile signals translocated to each root. These shoot-derived polypeptides, which the authors named CEP DOWNSTREAM 1 (CEPD1) and CEPD2, upregulate the expression of the nitrate transporter gene NRT2.1 in roots specifically when nitrate is present in the rhizosphere.
      Title: Shoot-to-root mobile polypeptides involved in systemic regulation of nitrogen acquisition.
    8. A major role for the high-affinity nitrate transporter NRT2.1 in increasing root hydraulic conductivity
      Title: Dual regulation of root hydraulic conductivity and plasma membrane aquaporins by plant nitrate accumulation and high-affinity nitrate transporter NRT2.1.
    9. Arabidopsis ELONGATED HYPOCOTYL5 (HY5) is a shoot-to-root mobile signal that mediates light promotion of root growth and nitrate uptake. Shoot-derived HY5 auto-activates root HY5 and also promotes root nitrate uptake by activating NRT2.1, a gene encoding a high-affinity nitrate transporter.
      Title: Shoot-to-Root Mobile Transcription Factor HY5 Coordinates Plant Carbon and Nitrogen Acquisition.
    10. Glucose elevates NRT2.1 protein levels.
      Title: Glucose elevates NITRATE TRANSPORTER2.1 protein levels and nitrate transport activity independently of its HEXOKINASE1-mediated stimulation of NITRATE TRANSPORTER2.1 expression.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_100684.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables nitrate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nitrate transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lateral root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nitrate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nitrate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nitrate IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    nitrate transporter 2:1
    NP_172288.1
    • nitrate transporter 2:1 (NRT2:1); CONTAINS InterPro DOMAIN/s: Major facilitator superfamily MFS-1 (InterPro:IPR011701), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: nitrate transporter 2.2 (TAIR:AT1G08100.1); Has 5150 Blast hits to 5022 proteins in 1376 species: Archae - 45; Bacteria - 4402; Metazoa - 22; Fungi - 274; Plants - 247; Viruses - 0; Other Eukaryotes - 160 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2524023..2526322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100684.3 → NP_172288.1  nitrate transporter 2:1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172288.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82811
      UniProtKB/TrEMBL
      A0A178WIP7, A0A5S9T7V0, A0A7G2DTS0
      Conserved Domains (1) summary
      PLN00028
      Location:28 → 506
      PLN00028; nitrate transmembrane transporter; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82811.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools