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    PFI tubulin folding cofactor E / Pfifferling (PFI) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843485, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PFI
    Official Full Name
    tubulin folding cofactor E / Pfifferling (PFI)
    Primary source
    TAIR:AT1G71440
    Locus tag
    AT1G71440
    See related
    Araport:AT1G71440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F3I17.21; F3I17_21; PFIFFERLING; TFC E; TUBULIN-FOLDING COFACTOR E
    Summary
    Encodes tubulin-folding cofactor E. Mutant embryos consist of one or a few grossly enlarged cells, surrounded by an endosperm that fails to cellularize and contains a few big nuclei.
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    Genomic context

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    See PFI in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Sequence:
    Chromosome: 1; NC_003070.9 (26921060..26924431, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene Pentatricopeptide repeat (PPR-like) superfamily protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the pilz group genes disrupt the microtubule cytoskeleton and uncouple cell cycle progression from cell division in Arabidopsis embryo and endosperm. Mayer U, et al. Eur J Cell Biol, 1999 Feb. PMID 10099932
    2. The Arabidopsis PILZ group genes encode tubulin-folding cofactor orthologs required for cell division but not cell growth. Steinborn K, et al. Genes Dev, 2002 Apr 15. PMID 11959844, Free PMC Article
    3. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_105813.4

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokinesis by cell plate formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 

    General protein information

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    Preferred Names
    tubulin folding cofactor E / Pfifferling (PFI)
    NP_565017.1
    • PFIFFERLING (PFI); INVOLVED IN: tubulin complex assembly, embryo development ending in seed dormancy, cytokinesis; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cytoskeleton-associated protein, CAP-Gly (InterPro:IPR000938); Has 7270 Blast hits to 6366 proteins in 489 species: Archae - 4; Bacteria - 1949; Metazoa - 3435; Fungi - 492; Plants - 819; Viruses - 0; Other Eukaryotes - 571 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26921060..26924431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105813.4 → NP_565017.1  tubulin folding cofactor E / Pfifferling (PFI) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565017.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GRL7, Q8L405, Q9C9I1
      UniProtKB/TrEMBL
      A0A178VZZ6, A0A5S9WRG1, A0A654EN45
      Conserved Domains (4) summary
      smart01052
      Location:12 → 81
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      sd00033
      Location:136 → 161
      LRR_RI; leucine-rich repeat [structural motif]
      cd17044
      Location:446 → 528
      Ubl_TBCE; ubiquitin-like (Ubl) domain found in tubulin-folding cofactor E (TBCE) and similar proteins
      cd21340
      Location:157 → 384
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GRL7.1

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