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    PK1 protein-serine kinase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820020, updated on 18-Sep-2024

    Summary

    Official Symbol
    PK1
    Official Full Name
    protein-serine kinase 1
    Primary source
    TAIR:AT3G08730
    Locus tag
    AT3G08730
    See related
    Araport:AT3G08730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA PROTEIN-SERINE KINASE 1; ARABIDOPSIS THALIANA PROTEIN-SERINE KINASE 6; ATPK1; ATPK6; ATS6K1; P70 RIBOSOMAL S6 KINASE; PK6; PROTEIN-SERINE KINASE; protein-serine kinase 1; ROTEIN-SERINE KINASE 6; S6K1
    Summary
    Encodes a protein-serine kinase that phosphorylates ribosomal protein in vitro. Activation of AtS6k is regulated by 1-naphthylacetic acid and kinetin, at least in part, via a lipid kinase-dependent pathway. Involved in translational up-regulation of ribosomal proteins. Phosphorylated by PDK1. Interacts with RAPTOR1, which in turn interacts with TOR. SPK6 activity is affected by osmotic stress, and plants overexpressing S6k1 are hypersensitive to osmotic stress. The gene is expressed in all tissues examined, with highest expression level detected in metabolically active tissues.
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    Genomic context

    See PK1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (2651321..2654212, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene thioredoxin H-type 9 Neighboring gene serine/threonine protein kinase 2 Neighboring gene elongation factor P (EF-P) family protein Neighboring gene F-box and associated interaction domains-containing protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    NM_001337768.1
    NM_111707.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein-serine kinase 1
    NP_187485.1
    • protein-serine kinase 1 (PK1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase, C-terminal (InterPro:IPR017892), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), AGC-kinase, C-terminal (InterPro:IPR000961), Protein kinase, catalytic domain (InterPro:IPR000719); BEST Arabidopsis thaliana protein match is: serine/threonine protein kinase 2 (TAIR:AT3G08720.2); Has 134224 Blast hits to 132007 proteins in 4588 species: Archae - 200; Bacteria - 15979; Metazoa - 48799; Fungi - 13454; Plants - 32927; Viruses - 586; Other Eukaryotes - 22279 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2651321..2654212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111707.4NP_187485.1  protein-serine kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187485.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42818, Q8LFC1
      UniProtKB/TrEMBL
      A0A178VLF0, A0A5S9XA91
      Conserved Domains (2) summary
      smart00133
      Location:390452
      S_TK_X; Extension to Ser/Thr-type protein kinases
      cd05123
      Location:140389
      STKc_AGC; Catalytic domain of AGC family Serine/Threonine Kinases
    2. NM_001337768.1NP_001326081.1  protein-serine kinase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42818, Q8LFC1
      UniProtKB/TrEMBL
      A0A178VLF0, A0A5S9XA91
      Conserved Domains (2) summary
      smart00133
      Location:390452
      S_TK_X; Extension to Ser/Thr-type protein kinases
      cd05123
      Location:140389
      STKc_AGC; Catalytic domain of AGC family Serine/Threonine Kinases