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    FAD5 fatty acid desaturase 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820828, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FAD5
    Official Full Name
    fatty acid desaturase 5
    Primary source
    TAIR:AT3G15850
    Locus tag
    AT3G15850
    See related
    Araport:AT3G15850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ADS3; AtADS3; FADB; fatty acid desaturase 5; FATTY ACID DESATURASE B; JB67
    Summary
    Chloroplastic enzyme responsible for the synthesis of 16:1 fatty acids from galactolipids and sulpholipids. Uses ferredoxin as electron donor.
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    Genomic context

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    See FAD5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (5358601..5361185)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene phosphatidic acid phosphatase-related / PAP2-like protein Neighboring gene post-illumination chlorophyll fluorescence increase Neighboring gene plant self-incompatibility protein S1 family protein Neighboring gene Fatty acid desaturase family protein Neighboring gene WUS-interacting protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FATTY ACID DESATURASE5 Is Required to Induce Autoimmune Responses in Gigantic Chloroplast Mutants of Arabidopsis. Li B, et al. Plant Cell, 2020 Oct. PMID 32796124, Free PMC Article
    2. A suppressor of fab1 challenges hypotheses on the role of thylakoid unsaturation in photosynthetic function. Barkan L, et al. Plant Physiol, 2006 Jul. PMID 16698898, Free PMC Article
    3. Identification of the Arabidopsis palmitoyl-monogalactosyldiacylglycerol delta7-desaturase gene FAD5, and effects of plastidial retargeting of Arabidopsis desaturases on the fad5 mutant phenotype. Heilmann I, et al. Plant Physiol, 2004 Dec. PMID 15579662, Free PMC Article
    4. Photoinhibition in mutants of Arabidopsis deficient in thylakoid unsaturation. Vijayan P, et al. Plant Physiol, 2002 Jun. PMID 12068126, Free PMC Article
    5. The impact of alteration of polyunsaturated fatty acid levels on C6-aldehyde formation of Arabidopsis thaliana leaves. Zhuang H, et al. Plant Physiol, 1996 Jul. PMID 8754681, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FATTY ACID DESATURASE5 Is Required to Induce Autoimmune Responses in Gigantic Chloroplast Mutants of Arabidopsis.
      Title: FATTY ACID DESATURASE5 Is Required to Induce Autoimmune Responses in Gigantic Chloroplast Mutants of Arabidopsis.
    2. Nonsense mutation at this site affects activity of the plastidial palmitoyl-monogalactosyldiacylglycerol Delta7-desaturase FAD5.
      Title: Identification of the Arabidopsis palmitoyl-monogalactosyldiacylglycerol delta7-desaturase gene FAD5, and effects of plastidial retargeting of Arabidopsis desaturases on the fad5 mutant phenotype.
    3. The overall leaf fatty acid composition of S31 plants contained 31% 16:0 compared with 23% in fab1 and 17% in wild type. Biochemical and genetic analysis showed that S31 plants contain a new allele of fatty acid desaturation 5 (fad5), fad5-2.
      Title: A suppressor of fab1 challenges hypotheses on the role of thylakoid unsaturation in photosynthetic function.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_112455.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables palmitoyl-[glycerolipid] 7-desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-[glycerolipid] 7-desaturase activity IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Process Evidence Code Pubs
    involved_in oxylipin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within photoinhibition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in unsaturated fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within unsaturated fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in thylakoid TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fatty acid desaturase 5
    NP_566529.1
    • fatty acid desaturase 5 (FAD5); CONTAINS InterPro DOMAIN/s: Fatty acid desaturase, type 1, core (InterPro:IPR015876), Fatty acid desaturase, type 1 (InterPro:IPR005804); BEST Arabidopsis thaliana protein match is: Fatty acid desaturase family protein (TAIR:AT3G15870.1); Has 3424 Blast hits to 3424 proteins in 822 species: Archae - 0; Bacteria - 1534; Metazoa - 801; Fungi - 236; Plants - 106; Viruses - 4; Other Eukaryotes - 743 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5358601..5361185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112455.4 → NP_566529.1  fatty acid desaturase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566529.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LCQ8, Q949X0, Q9LVZ4
      UniProtKB/TrEMBL
      A0A178VBZ6, A0A5S9XD27, A0A654F7K4, A0A7G2EQD3
      Conserved Domains (1) summary
      cl00615
      Location:96 → 369
      Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q949X0.2

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