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    PLSP1 plastidic type i signal peptidase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822055, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PLSP1
    Official Full Name
    plastidic type i signal peptidase 1
    Primary source
    TAIR:AT3G24590
    Locus tag
    AT3G24590
    See related
    Araport:AT3G24590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    plastidic type i signal peptidase 1
    Summary
    Encodes a signal peptidase Plsp1 (plastidic type I signal peptidase 1). Required for thylakoid development. Functions in the maturation of the 75-kD component of the translocon at the outer envelope membrane of chloroplasts and oxygen evolving complex subunit 33 (OE33). Involved in the maturation of PsbO, plastocyanin and FtsH2/8.
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    Genomic context

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    See PLSP1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (8970632..8972464)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Peroxisomal membrane 22 kDa (Mpv17/PMP22) family protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene late embryogenesis abundant protein, group 2 Neighboring gene late embryogenesis abundant protein, group 2 Neighboring gene Galactose oxidase/kelch repeat superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane Chaperoning of a Thylakoid Protease Whose Structural Stability Is Modified by the Protonmotive Force. McKinnon LJ, et al. Plant Cell, 2020 May. PMID 32169961, Free PMC Article
    2. Plastidic type I signal peptidase 1 is a redox-dependent thylakoidal processing peptidase. Midorikawa T, et al. Plant J, 2014 Nov. PMID 25182596
    3. The significance of protein maturation by plastidic type I signal peptidase 1 for thylakoid development in Arabidopsis chloroplasts. Shipman-Roston RL, et al. Plant Physiol, 2010 Mar. PMID 20097790, Free PMC Article
    4. Suborganellar localization of plastidic type I signal peptidase 1 depends on chloroplast development. Shipman RL, et al. FEBS Lett, 2009 Mar 4. PMID 19223000
    5. Chaperone-assisted Post-translational Transport of Plastidic Type I Signal Peptidase 1. Endow JK, et al. J Biol Chem, 2015 Nov 27. PMID 26446787, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Membrane Chaperoning of a Thylakoid Protease Whose Structural Stability Is Modified by the Protonmotive Force.
      Title: Membrane Chaperoning of a Thylakoid Protease Whose Structural Stability Is Modified by the Protonmotive Force.
    2. Plsp1 is a redox-dependent signal peptidase in the thylakoid lumen.
      Title: Plastidic type I signal peptidase 1 is a redox-dependent thylakoidal processing peptidase.
    3. During import-chase assays using intact chloroplasts, Plsp1 was incorporated into a soluble 700-kDa complex that co-migrated with the Cpn60 complex before inserting into the membrane.
      Title: Chaperone-assisted Post-translational Transport of Plastidic Type I Signal Peptidase 1.
    4. One of the thylakoidal processing peptidase isoforms, Plsp1, forms a stable complex with PGRL1.
      Title: Stable complex formation of thylakoidal processing peptidase and PGRL1.
    5. Lack of Plsp1 causes a reduction in accumulation of thylakoid proteins and that Plsp1 is involved in maturation of two additional lumenal proteins, OE23 and plastocyanin.
      Title: The significance of protein maturation by plastidic type I signal peptidase 1 for thylakoid development in Arabidopsis chloroplasts.
    6. Plsp1 is evenly distributed in the envelope and thylakoids of developing chloroplasts in meristems
      Title: Suborganellar localization of plastidic type I signal peptidase 1 depends on chloroplast development.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001338695.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within thylakoid membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in chloroplast thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plastidic type i signal peptidase 1
    NP_001319633.1
    • plastidic type i signal peptidase 1 (PLSP1); FUNCTIONS IN: peptidase activity; INVOLVED IN: proteolysis, thylakoid membrane organization, protein maturation; LOCATED IN: chloroplast thylakoid membrane, chloroplast, membrane, plastid envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase S24/S26A/S26B/S26C, beta-ribbon domain (InterPro:IPR011056), Peptidase S24/S26A/S26B/S26C (InterPro:IPR015927), Peptidase S26A, signal peptidase I, conserved site (InterPro:IPR019758), Peptidase S26, conserved region (InterPro:IPR019533), Peptidase S26A, signal peptidase I (InterPro:IPR000223), Peptidase S26A, signal peptidase I, serine active site (InterPro:IPR019756); BEST Arabidopsis thaliana protein match is: Peptidase S24/S26A/S26B/S26C family protein (TAIR:AT1G06870.1); Has 9773 Blast hits to 9438 proteins in 2404 species: Archae - 0; Bacteria - 7280; Metazoa - 206; Fungi - 105; Plants - 230; Viruses - 0; Other Eukaryotes - 1952 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      8970632..8972464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113370.3 → NP_189102.3  plastidic type i signal peptidase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VD22, A0A1I9LMR3

    2. NM_001338695.1 → NP_001319633.1  plastidic type i signal peptidase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q66GJ6, Q8H0W1, Q9LV44
      UniProtKB/TrEMBL
      A0A178VD22
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H0W1.2

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