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    VRN1 AP2/B3-like transcriptional factor family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821432, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VRN1
    Official Full Name
    AP2/B3-like transcriptional factor family protein
    Primary source
    TAIR:AT3G18990
    Locus tag
    AT3G18990
    See related
    Araport:AT3G18990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    REDUCED VERNALIZATION RESPONSE 1; REM39; REPRODUCTIVE MERISTEM 39
    Summary
    Required for vernalization. Essential for the complete repression of FLC in vernalized plants. Required for the methylation of histone H3
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    Genomic context

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    See VRN1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (6548127..6552055, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene AP2/B3-like transcriptional factor family protein Neighboring gene mitochondrial editing factor 20 Neighboring gene EIN2 targeting protein1 Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene ncRNA Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Charge Segregation in the Intrinsically Disordered Region Governs VRN1 and DNA Liquid-like Phase Separation Robustness. Wang Y, et al. J Mol Biol, 2021 Nov 5. PMID 34571015
    2. The Arabidopsis B3 domain protein VERNALIZATION1 (VRN1) is involved in processes essential for development, with structural and mutational studies revealing its DNA-binding surface. King GJ, et al. J Biol Chem, 2013 Feb 1. PMID 23255593, Free PMC Article
    3. Expression, purification and preliminary X-ray diffraction studies of VERNALIZATION1(208-341) from Arabidopsis thaliana. King G, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 Mar 1. PMID 19255487, Free PMC Article
    4. Multiple roles of Arabidopsis VRN1 in vernalization and flowering time control. Levy YY, et al. Science, 2002 Jul 12. PMID 12114624
    5. Arabidopsis mutants showing an altered response to vernalization. Chandler J, et al. Plant J, 1996 Oct. PMID 8998499

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Charge Segregation in the Intrinsically Disordered Region Governs VRN1 and DNA Liquid-like Phase Separation Robustness.
      Title: Charge Segregation in the Intrinsically Disordered Region Governs VRN1 and DNA Liquid-like Phase Separation Robustness.
    2. Although VRN1 is sequence-nonspecific in DNA binding, it has a defined DNA-binding surface.
      Title: The Arabidopsis B3 domain protein VERNALIZATION1 (VRN1) is involved in processes essential for development, with structural and mutational studies revealing its DNA-binding surface.
    3. Preliminary X-ray diffraction data analysis revealed that the VRN1(208-341) crystal diffracted to 2.1 A.
      Title: Expression, purification and preliminary X-ray diffraction studies of VERNALIZATION1(208-341) from Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_112785.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vernalization response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AP2/B3-like transcriptional factor family protein
    NP_188529.2
    • REDUCED VERNALIZATION RESPONSE 1 (VRN1); CONTAINS InterPro DOMAIN/s: Transcriptional factor B3 (InterPro:IPR003340); BEST Arabidopsis thaliana protein match is: related to vernalization1 1 (TAIR:AT1G49480.1); Has 683 Blast hits to 597 proteins in 20 species: Archae - 0; Bacteria - 0; Metazoa - 1; Fungi - 0; Plants - 682; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6548127..6552055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001338374.1 → NP_001326749.1  AP2/B3-like transcriptional factor family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQ83, A0A654F8L2

    2. NM_112785.5 → NP_188529.2  AP2/B3-like transcriptional factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188529.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L3W1, Q9LJ67
      UniProtKB/TrEMBL
      A0A178VIS1, A0A5S9XF37, A0A654F8L2
      Conserved Domains (2) summary
      cd10017
      Location:5 → 96
      B3_DNA; Plant-specific B3-DNA binding domain
      pfam02362
      Location:244 → 338
      B3; B3 DNA binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L3W1.1

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