U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CYSB cystatin B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820428, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CYSB
    Official Full Name
    cystatin B
    Primary source
    TAIR:AT3G12490
    Locus tag
    AT3G12490
    See related
    Araport:AT3G12490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA PHYTOCYSTATIN 6; ATCYS6; ATCYSB; cystatin B
    Summary
    Encodes a protein with cysteine proteinase inhibitor activity. Overexpression increases tolerance to abiotic stressors (i.e.salt,osmotic, cold stress).
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CYSB in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (3960401..3961920, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein Neighboring gene nuclear factor Y, subunit C11 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene basic chitinase Neighboring gene MADS-box family protein Neighboring gene ncRNA Neighboring gene sulfate transporter 4;2

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Regulation of seed germination and seedling growth by an Arabidopsis phytocystatin isoform, AtCYS6. Hwang JE, et al. Plant Cell Rep, 2009 Nov. PMID 19690865, Free PMC Article
    2. Two cysteine proteinase inhibitors from Arabidopsis thaliana, AtCYSa and AtCYSb, increasing the salt, drought, oxidation and cold tolerance. Zhang X, et al. Plant Mol Biol, 2008 Sep. PMID 18523728
    3. XYLEM CYSTEINE PEPTIDASE 1 and its inhibitor CYSTATIN 6 regulate pattern-triggered immunity by modulating the stability of the NADPH oxidase RESPIRATORY BURST OXIDASE HOMOLOG D. Liu Y, et al. Plant Cell, 2024 Jan 30. PMID 37820743, Free PMC Article
    4. Arabidopsis cysteine proteinase inhibitor AtCYSb interacts with a Ca(2+)-dependent nuclease, AtCaN2. Guo K, et al. FEBS Lett, 2013 Nov 1. PMID 24076026
    5. Identification of BZR1-interacting proteins as potential components of the brassinosteroid signaling pathway in Arabidopsis through tandem affinity purification. Wang C, et al. Mol Cell Proteomics, 2013 Dec. PMID 24019147, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001337993.1
    NM_180239.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cobalt ion binding HDA PubMed 
    enables cysteine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cystatin B
    NP_001319530.1
    • cystatin B (CYSB); FUNCTIONS IN: cysteine-type endopeptidase inhibitor activity, cobalt ion binding; INVOLVED IN: response to abiotic stimulus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Proteinase inhibitor I25, cystatin, conserved site (InterPro:IPR018073), Proteinase inhibitor I25, cystatin (InterPro:IPR000010), Proteinase inhibitor I25, cystatin, conserved region (InterPro:IPR020381); BEST Arabidopsis thaliana protein match is: Cystatin/monellin family protein (TAIR:AT5G05110.1); Has 755 Blast hits to 732 proteins in 99 species: Archae - 0; Bacteria - 2; Metazoa - 28; Fungi - 0; Plants - 721; Viruses - 0; Other Eukaryotes - 4 (source: NCBI BLink).
    NP_850570.2
    • cystatin B (CYSB); FUNCTIONS IN: cysteine-type endopeptidase inhibitor activity, cobalt ion binding; INVOLVED IN: response to abiotic stimulus; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Proteinase inhibitor I25, cystatin, conserved site (InterPro:IPR018073), Proteinase inhibitor I25, cystatin, conserved region (InterPro:IPR020381), Proteinase inhibitor I25, cystatin (InterPro:IPR000010); BEST Arabidopsis thaliana protein match is: Cystatin/monellin family protein (TAIR:AT5G05110.1); Has 755 Blast hits to 732 proteins in 99 species: Archae - 0; Bacteria - 2; Metazoa - 28; Fungi - 0; Plants - 721; Viruses - 0; Other Eukaryotes - 4 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3960401..3961920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180239.4 → NP_850570.2  cystatin B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850570.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8H0X6, Q8VZA2, Q9FUB0, Q9LHF9
      UniProtKB/TrEMBL
      A0A5S9XBM7
      Conserved Domains (2) summary
      smart00043
      Location:35 → 124
      CY; Cystatin-like domain
      cl09238
      Location:146 → 207
      CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

    2. NM_001337993.1 → NP_001319530.1  cystatin B [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VK31, A0A2H1ZEH9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H0X6.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.