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    RMA1 RING membrane-anchor 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825654, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RMA1
    Official Full Name
    RING membrane-anchor 1
    Primary source
    TAIR:AT4G03510
    Locus tag
    AT4G03510
    See related
    Araport:AT4G03510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRMA1; F9H3.14; F9H3_14; RING membrane-anchor 1
    Summary
    RMA1 encodes a novel 28 kDa protein with a RING finger motif and a C-terminal membrane-anchoring domain that is involved in the secretory pathway. Has E3 ubiquitin ligase activity.
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    Genomic context

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    See RMA1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (1557120..1559437, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Ankyrin repeat family protein Neighboring gene uncharacterized protein Neighboring gene Ankyrin repeat family protein Neighboring gene uncharacterized protein Neighboring gene Thioredoxin superfamily protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RMA1, an Arabidopsis thaliana gene whose cDNA suppresses the yeast sec15 mutation, encodes a novel protein with a RING finger motif and a membrane anchor. Matsuda N, et al. Plant Cell Physiol, 1998 May. PMID 9664717
    2. Drought stress-induced Rma1H1, a RING membrane-anchor E3 ubiquitin ligase homolog, regulates aquaporin levels via ubiquitination in transgenic Arabidopsis plants. Lee HK, et al. Plant Cell, 2009 Feb. PMID 19234086, Free PMC Article
    3. Characterization of three Arabidopsis homologs of human RING membrane anchor E3 ubiquitin ligase. Son O, et al. Plant Cell Rep, 2009 Apr. PMID 19224217
    4. Rma1, a novel type of RING finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase. Matsuda N, et al. J Cell Sci, 2001 May. PMID 11329381
    5. Ubiquitin ligase OsRINGzf1 regulates drought resistance by controlling the turnover of OsPIP2;1. Chen S, et al. Plant Biotechnol J, 2022 Sep. PMID 35587579, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RMA1, RMA2 and RMA3 all have E3 ubiquitin ligase activity and are localized to the endoplasmic reticulum.
      Title: Characterization of three Arabidopsis homologs of human RING membrane anchor E3 ubiquitin ligase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001340463.1
    NM_001340464.1
    NM_116589.3
    NM_202777.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein exit from endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within secretion by cell IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RING membrane-anchor 1
    NP_001319862.1
    • RING membrane-anchor 1 (RMA1); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING membrane-anchor 2 (TAIR:AT4G28270.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_192260.1
    • RING membrane-anchor 1 (RMA1); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING membrane-anchor 2 (TAIR:AT4G28270.1); Has 3991 Blast hits to 3981 proteins in 266 species: Archae - 0; Bacteria - 0; Metazoa - 2157; Fungi - 553; Plants - 874; Viruses - 19; Other Eukaryotes - 388 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      1557120..1559437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116589.3 → NP_192260.1  RING membrane-anchor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192260.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64425
      UniProtKB/TrEMBL
      A0A178V3K7, A0A5S9XPV8
      Conserved Domains (2) summary
      PLN03208
      Location:40 → 249
      PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
      cd00162
      Location:47 → 100
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_001340463.1 → NP_001319862.1  RING membrane-anchor 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64425
      UniProtKB/TrEMBL
      A0A178V3K7, A0A5S9XPV8

    3. NM_202777.2 → NP_974506.1  RING membrane-anchor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974506.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64425
      UniProtKB/TrEMBL
      A0A178V3K7, A0A5S9XPV8
      Conserved Domains (2) summary
      PLN03208
      Location:40 → 249
      PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
      cd00162
      Location:47 → 100
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    4. NM_001340464.1 → NP_001329467.1  RING membrane-anchor 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64425
      UniProtKB/TrEMBL
      A0A178V3K7, A0A5S9XPV8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64425.1

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